TY - JOUR
T1 - Diabetes and the gastrointestinal tract
AU - Meldgaard, T.
AU - Brock, C.
PY - 2019/7
Y1 - 2019/7
N2 - Gastrointestinal (GI) complications of diabetes mellitus are common and result in a significant diminution in health-related quality of life. Diabetes can affect almost every part of GI tract from the oesophagus to the rectum, and causes a variety of symptoms including reflux, heartburn, nausea, vomiting, abdominal pain, diarrhoea and constipation. Diabetes-induced GI complications are collectively referred to as diabetic enteropathy. Over recent years, the investigation of the underlying pathogenesis of diabetes-induced GI complications has provided objective evidence of abnormalities in the enteric nervous system, which is essential for normal motility within the GI tract. The diagnosis of diabetic enteropathy is complex, and other causes of GI symptoms should be excluded. There is currently no cure for diabetic enteropathy. Hence, the goals of treatment are to slow progression, relieve symptoms and manage complications. Key to this is tight glycaemic control, dietary advice and occasionally pharmacological treatment with, for example, prokinetics.
AB - Gastrointestinal (GI) complications of diabetes mellitus are common and result in a significant diminution in health-related quality of life. Diabetes can affect almost every part of GI tract from the oesophagus to the rectum, and causes a variety of symptoms including reflux, heartburn, nausea, vomiting, abdominal pain, diarrhoea and constipation. Diabetes-induced GI complications are collectively referred to as diabetic enteropathy. Over recent years, the investigation of the underlying pathogenesis of diabetes-induced GI complications has provided objective evidence of abnormalities in the enteric nervous system, which is essential for normal motility within the GI tract. The diagnosis of diabetic enteropathy is complex, and other causes of GI symptoms should be excluded. There is currently no cure for diabetic enteropathy. Hence, the goals of treatment are to slow progression, relieve symptoms and manage complications. Key to this is tight glycaemic control, dietary advice and occasionally pharmacological treatment with, for example, prokinetics.
KW - Diabetes complications
KW - diabetes mellitus
KW - diabetic neuropathies
KW - enteric nervous system
KW - gastrointestinal motility
KW - gastrointestinal transit
UR - http://www.scopus.com/inward/record.url?scp=85066270890&partnerID=8YFLogxK
U2 - 10.1016/j.mpmed.2019.04.011
DO - 10.1016/j.mpmed.2019.04.011
M3 - Journal article
SN - 1357-3039
VL - 47
SP - 454
EP - 459
JO - Medicine (United Kingdom)
JF - Medicine (United Kingdom)
IS - 7
ER -