Diabetic Enteropathy: From Molecule to Mechanism-Based Treatment

Theresa Meldgaard, Søren Schou Olesen, Adam D. Farmer, Klaus Krogh, Anne Astrid Wendel, Birgitte Brock, Asbjørn Mohr Drewes, Christina Brock

Publikation: Bidrag til tidsskriftReview (oversigtsartikel)Forskningpeer review

1 Citation (Scopus)
63 Downloads (Pure)

Resumé

The incidence of the micro- and macrovascular complications of diabetes is rising, mirroring the increase in the worldwide prevalence. Arguably, the most common microvascular complication is neuropathy, leading to deleterious changes in both the structure and function of neurons. Amongst the various neuropathies with the highest symptom burden are those associated with alterations in the enteric nervous system, referred to as diabetic enteropathy. The primary aim of this review is to provide a contemporaneous summary of pathophysiology of diabetic enteropathy thereby allowing a ``molecule to mechanism'' approach to treatment, which will include 4 distinct aspects. Firstly, the aim is to provide an overview of the diabetes-induced structural remodelling, biochemical dysfunction, immune-mediated alterations, and inflammatory properties of the enteric nervous system and associated structures. Secondly, the aim is to provide a synopsis of the clinical relevance of diabetic enteropathy. Thirdly, the aim is to discuss the various patient-reported outcome measures and the objective modalities for evaluating dysmotility, and finally, the aim is to outline the clinical management and different treatment options that are available. Given the burden of disease that diabetic enteropathy causes, earlier recognition is needed allowing prompt investigation and intervention, which may lead to improvements in quality of life for sufferers.
OriginalsprogEngelsk
Artikelnummer3827301
TidsskriftJournal of Diabetes Research
Vol/bind2018
Sider (fra-til)1-12
Antal sider12
ISSN2314-6745
DOI
StatusUdgivet - 2018

Citer dette

Meldgaard, Theresa ; Olesen, Søren Schou ; Farmer, Adam D. ; Krogh, Klaus ; Wendel, Anne Astrid ; Brock, Birgitte ; Drewes, Asbjørn Mohr ; Brock, Christina. / Diabetic Enteropathy : From Molecule to Mechanism-Based Treatment. I: Journal of Diabetes Research. 2018 ; Bind 2018. s. 1-12.
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abstract = "The incidence of the micro- and macrovascular complications of diabetes is rising, mirroring the increase in the worldwide prevalence. Arguably, the most common microvascular complication is neuropathy, leading to deleterious changes in both the structure and function of neurons. Amongst the various neuropathies with the highest symptom burden are those associated with alterations in the enteric nervous system, referred to as diabetic enteropathy. The primary aim of this review is to provide a contemporaneous summary of pathophysiology of diabetic enteropathy thereby allowing a ``molecule to mechanism'' approach to treatment, which will include 4 distinct aspects. Firstly, the aim is to provide an overview of the diabetes-induced structural remodelling, biochemical dysfunction, immune-mediated alterations, and inflammatory properties of the enteric nervous system and associated structures. Secondly, the aim is to provide a synopsis of the clinical relevance of diabetic enteropathy. Thirdly, the aim is to discuss the various patient-reported outcome measures and the objective modalities for evaluating dysmotility, and finally, the aim is to outline the clinical management and different treatment options that are available. Given the burden of disease that diabetic enteropathy causes, earlier recognition is needed allowing prompt investigation and intervention, which may lead to improvements in quality of life for sufferers.",
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Diabetic Enteropathy : From Molecule to Mechanism-Based Treatment. / Meldgaard, Theresa; Olesen, Søren Schou; Farmer, Adam D.; Krogh, Klaus; Wendel, Anne Astrid; Brock, Birgitte; Drewes, Asbjørn Mohr; Brock, Christina.

I: Journal of Diabetes Research, Bind 2018, 3827301, 2018, s. 1-12.

Publikation: Bidrag til tidsskriftReview (oversigtsartikel)Forskningpeer review

TY - JOUR

T1 - Diabetic Enteropathy

T2 - From Molecule to Mechanism-Based Treatment

AU - Meldgaard, Theresa

AU - Olesen, Søren Schou

AU - Farmer, Adam D.

AU - Krogh, Klaus

AU - Wendel, Anne Astrid

AU - Brock, Birgitte

AU - Drewes, Asbjørn Mohr

AU - Brock, Christina

PY - 2018

Y1 - 2018

N2 - The incidence of the micro- and macrovascular complications of diabetes is rising, mirroring the increase in the worldwide prevalence. Arguably, the most common microvascular complication is neuropathy, leading to deleterious changes in both the structure and function of neurons. Amongst the various neuropathies with the highest symptom burden are those associated with alterations in the enteric nervous system, referred to as diabetic enteropathy. The primary aim of this review is to provide a contemporaneous summary of pathophysiology of diabetic enteropathy thereby allowing a ``molecule to mechanism'' approach to treatment, which will include 4 distinct aspects. Firstly, the aim is to provide an overview of the diabetes-induced structural remodelling, biochemical dysfunction, immune-mediated alterations, and inflammatory properties of the enteric nervous system and associated structures. Secondly, the aim is to provide a synopsis of the clinical relevance of diabetic enteropathy. Thirdly, the aim is to discuss the various patient-reported outcome measures and the objective modalities for evaluating dysmotility, and finally, the aim is to outline the clinical management and different treatment options that are available. Given the burden of disease that diabetic enteropathy causes, earlier recognition is needed allowing prompt investigation and intervention, which may lead to improvements in quality of life for sufferers.

AB - The incidence of the micro- and macrovascular complications of diabetes is rising, mirroring the increase in the worldwide prevalence. Arguably, the most common microvascular complication is neuropathy, leading to deleterious changes in both the structure and function of neurons. Amongst the various neuropathies with the highest symptom burden are those associated with alterations in the enteric nervous system, referred to as diabetic enteropathy. The primary aim of this review is to provide a contemporaneous summary of pathophysiology of diabetic enteropathy thereby allowing a ``molecule to mechanism'' approach to treatment, which will include 4 distinct aspects. Firstly, the aim is to provide an overview of the diabetes-induced structural remodelling, biochemical dysfunction, immune-mediated alterations, and inflammatory properties of the enteric nervous system and associated structures. Secondly, the aim is to provide a synopsis of the clinical relevance of diabetic enteropathy. Thirdly, the aim is to discuss the various patient-reported outcome measures and the objective modalities for evaluating dysmotility, and finally, the aim is to outline the clinical management and different treatment options that are available. Given the burden of disease that diabetic enteropathy causes, earlier recognition is needed allowing prompt investigation and intervention, which may lead to improvements in quality of life for sufferers.

U2 - 10.1155/2018/3827301

DO - 10.1155/2018/3827301

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JO - Journal of Diabetes Research

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