Dietary probiotic supplement positively affects sperm motility in obese murine models

Fereshteh Dardmeh, Hiva Alipour, Parisa Gazerani, Gerhard Van Der Horst, Benedict Kjærgaard, Erik Brandsborg, H. Ingolf Nielsen

Publikation: Bidrag til bog/antologi/rapport/konference proceedingKonferenceabstrakt i proceedingForskning

Resumé

Obesity in adult men in recent years has inconsistently been associated with low semen quality and sub-fecundity. Probiotics have gained high interest as alternatives to pharmacological compounds. However, their possible effect on male fertility has been less investigated. This study aimed at assessing the use of L.Rhamnusus on obese male fertility characteristics. We proposed that this probiotic can not only reduce the weight but in parallel would enhance sperm motility in obese male mice.
Diet-induced obese C57BL/6NTac mice were randomly assigned to 2 groups and treated with a single daily dose (1x109CFU) of L.Rhamnusus (test group) or physiological saline (control group) for 4 weeks. Sperm motility and kinematics were assessed by the Sperm Class Analyzer (SCA).
The control group maintained a raising trend in weight gain leading to a significant difference on week 5 continuing to week 8 whereas the DIO mice in the test group did not gain significant weight after the start of probiotic test. The test group showed a significantly higher progressive motility compared to the control group after 4 weeks of receiving the probiotic treatment.
L.Rhamnusus supplementation demonstrated a higher percentage of progressive sperm, suggesting a possible increase in pregnancy. The effect mechanism of L.Rhamnusus could be either through direct influence on sperm motility or indirectly due to the promotion of weight loss. The latter hypothesis is due to the fact that weight-loss leads to scrotal temperature decrease and hormonal balance affecting sperm kinetics and kinematics during maturation in the epididymis. These hypotheses require further investigation.
OriginalsprogEngelsk
TitelFinal programme, 18th World Congress of In Vitro Ferilization, ISIVF 2015, 27-30 September 2015, Copenhagen, Denmark
ForlagInternational Society of In Vitro Fertilization
Publikationsdatosep. 2015
Sider20, No. P9
StatusUdgivet - sep. 2015
BegivenhedWorld Congress of In Vitro Fertilization, ISIVF - Copenhagen, Danmark
Varighed: 27 sep. 201530 sep. 2015
Konferencens nummer: 18

Konference

KonferenceWorld Congress of In Vitro Fertilization, ISIVF
Nummer18
LandDanmark
ByCopenhagen
Periode27/09/201530/09/2015

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Sperm Motility
Probiotics
Dietary Supplements
Fertility
Spermatozoa
Obese Mice
Biomechanical Phenomena
Control Groups
Weight Gain
Weight Loss
Semen Analysis
Epididymis
Inbred C57BL Mouse
Obesity
Pharmacology
Diet
Weights and Measures
Pregnancy
Temperature
Therapeutics

Citer dette

Dardmeh, F., Alipour, H., Gazerani, P., Van Der Horst, G., Kjærgaard, B., Brandsborg, E., & Nielsen, H. I. (2015). Dietary probiotic supplement positively affects sperm motility in obese murine models. I Final programme, 18th World Congress of In Vitro Ferilization, ISIVF 2015, 27-30 September 2015, Copenhagen, Denmark (s. 20, No. P9). International Society of In Vitro Fertilization.
Dardmeh, Fereshteh ; Alipour, Hiva ; Gazerani, Parisa ; Van Der Horst, Gerhard ; Kjærgaard, Benedict ; Brandsborg, Erik ; Nielsen, H. Ingolf. / Dietary probiotic supplement positively affects sperm motility in obese murine models. Final programme, 18th World Congress of In Vitro Ferilization, ISIVF 2015, 27-30 September 2015, Copenhagen, Denmark. International Society of In Vitro Fertilization, 2015. s. 20, No. P9
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Dardmeh, F, Alipour, H, Gazerani, P, Van Der Horst, G, Kjærgaard, B, Brandsborg, E & Nielsen, HI 2015, Dietary probiotic supplement positively affects sperm motility in obese murine models. i Final programme, 18th World Congress of In Vitro Ferilization, ISIVF 2015, 27-30 September 2015, Copenhagen, Denmark. International Society of In Vitro Fertilization, s. 20, No. P9, World Congress of In Vitro Fertilization, ISIVF, Copenhagen, Danmark, 27/09/2015.

Dietary probiotic supplement positively affects sperm motility in obese murine models. / Dardmeh, Fereshteh; Alipour, Hiva; Gazerani, Parisa; Van Der Horst, Gerhard; Kjærgaard, Benedict; Brandsborg, Erik; Nielsen, H. Ingolf.

Final programme, 18th World Congress of In Vitro Ferilization, ISIVF 2015, 27-30 September 2015, Copenhagen, Denmark. International Society of In Vitro Fertilization, 2015. s. 20, No. P9.

Publikation: Bidrag til bog/antologi/rapport/konference proceedingKonferenceabstrakt i proceedingForskning

TY - ABST

T1 - Dietary probiotic supplement positively affects sperm motility in obese murine models

AU - Dardmeh, Fereshteh

AU - Alipour, Hiva

AU - Gazerani, Parisa

AU - Van Der Horst, Gerhard

AU - Kjærgaard, Benedict

AU - Brandsborg, Erik

AU - Nielsen, H. Ingolf

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N2 - Obesity in adult men in recent years has inconsistently been associated with low semen quality and sub-fecundity. Probiotics have gained high interest as alternatives to pharmacological compounds. However, their possible effect on male fertility has been less investigated. This study aimed at assessing the use of L.Rhamnusus on obese male fertility characteristics. We proposed that this probiotic can not only reduce the weight but in parallel would enhance sperm motility in obese male mice.Diet-induced obese C57BL/6NTac mice were randomly assigned to 2 groups and treated with a single daily dose (1x109CFU) of L.Rhamnusus (test group) or physiological saline (control group) for 4 weeks. Sperm motility and kinematics were assessed by the Sperm Class Analyzer (SCA). The control group maintained a raising trend in weight gain leading to a significant difference on week 5 continuing to week 8 whereas the DIO mice in the test group did not gain significant weight after the start of probiotic test. The test group showed a significantly higher progressive motility compared to the control group after 4 weeks of receiving the probiotic treatment. L.Rhamnusus supplementation demonstrated a higher percentage of progressive sperm, suggesting a possible increase in pregnancy. The effect mechanism of L.Rhamnusus could be either through direct influence on sperm motility or indirectly due to the promotion of weight loss. The latter hypothesis is due to the fact that weight-loss leads to scrotal temperature decrease and hormonal balance affecting sperm kinetics and kinematics during maturation in the epididymis. These hypotheses require further investigation.

AB - Obesity in adult men in recent years has inconsistently been associated with low semen quality and sub-fecundity. Probiotics have gained high interest as alternatives to pharmacological compounds. However, their possible effect on male fertility has been less investigated. This study aimed at assessing the use of L.Rhamnusus on obese male fertility characteristics. We proposed that this probiotic can not only reduce the weight but in parallel would enhance sperm motility in obese male mice.Diet-induced obese C57BL/6NTac mice were randomly assigned to 2 groups and treated with a single daily dose (1x109CFU) of L.Rhamnusus (test group) or physiological saline (control group) for 4 weeks. Sperm motility and kinematics were assessed by the Sperm Class Analyzer (SCA). The control group maintained a raising trend in weight gain leading to a significant difference on week 5 continuing to week 8 whereas the DIO mice in the test group did not gain significant weight after the start of probiotic test. The test group showed a significantly higher progressive motility compared to the control group after 4 weeks of receiving the probiotic treatment. L.Rhamnusus supplementation demonstrated a higher percentage of progressive sperm, suggesting a possible increase in pregnancy. The effect mechanism of L.Rhamnusus could be either through direct influence on sperm motility or indirectly due to the promotion of weight loss. The latter hypothesis is due to the fact that weight-loss leads to scrotal temperature decrease and hormonal balance affecting sperm kinetics and kinematics during maturation in the epididymis. These hypotheses require further investigation.

M3 - Conference abstract in proceeding

SP - 20, No. P9

BT - Final programme, 18th World Congress of In Vitro Ferilization, ISIVF 2015, 27-30 September 2015, Copenhagen, Denmark

PB - International Society of In Vitro Fertilization

ER -

Dardmeh F, Alipour H, Gazerani P, Van Der Horst G, Kjærgaard B, Brandsborg E et al. Dietary probiotic supplement positively affects sperm motility in obese murine models. I Final programme, 18th World Congress of In Vitro Ferilization, ISIVF 2015, 27-30 September 2015, Copenhagen, Denmark. International Society of In Vitro Fertilization. 2015. s. 20, No. P9