DNA-selective hybridization and dual strand invasion of short double-stranded DNA using pyren-1-ylcarbonyl-functionalized 4'-C-piperazinomethyl-DNA.

Torsten Bryld, Torben Højland, Jesper Wengel

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

40 Citationer (Scopus)

Abstract

Incorporation of a novel pyren-1-ylcarbonyl-functionalized 4′-C-piperazinomethyl-DNA monomer into oligodeoxynucleotides leads to increased thermal stability of duplexes with DNA complements but reduced thermal stability of duplexes with RNA complements. This DNA-selective hybridization is explored for recognition of double-stranded DNA by a novel dual strand invasion approach
OriginalsprogEngelsk
TidsskriftChemical Communications
Vol/bind2004
Udgave nummer9
Sider (fra-til)1064-1065
ISSN1359-7345
DOI
StatusUdgivet - 2004
Udgivet eksterntJa

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