TY - JOUR
T1 - Effects of adipose thickness and muscle hardness on pressure pain sensitivity
AU - Finocchietti, Sara
AU - Mørch, Carsten Dahl
AU - Arendt-Nielsen, Lars
AU - Graven-Nielsen, Thomas
PY - 2011/6
Y1 - 2011/6
N2 - Objective: Pressure algometry is used for assessment of pain sensitivity. In this study the relation between tissue characteristics and pressure pain thresholds was investigated. Methods: Three-dimensional finite-element computer-models were developed to simulate the tissue stress and strain distribution during pressure stimulation on muscles with different hardness (I, II, III, IV (hardest)) and subcutaneous adipose tissue thickness (normal and thicker). The computer model was validated based on data recorded by computer-controlled pressure-induced muscle pain in 8 and 16 partecipants, respectively. Results: The experimental pressure-indentation curve fitted the outcome of the FE model (R>0.73). Stress and strain were extracted from the models at a known painful pressure stimulation level. PPT and PPTO were not significantly different in subjects with normal and thick adipose tissue in accordance with the simulation model where the strain in muscle tissue was comparable in the two conditions. The strain in adipose tissue was larger in subjects with thick adipose tissue compared with normal adipose thickness. In relaxed muscle (hardness I) the principal strain peaked at 0.12 in the adipose tissue, was reduced to 0.07 in the muscle tissue and 0.05 in the harder muscle. Significantly higher PPT and PPTO were recorded in harder compared with softer muscles (P
AB - Objective: Pressure algometry is used for assessment of pain sensitivity. In this study the relation between tissue characteristics and pressure pain thresholds was investigated. Methods: Three-dimensional finite-element computer-models were developed to simulate the tissue stress and strain distribution during pressure stimulation on muscles with different hardness (I, II, III, IV (hardest)) and subcutaneous adipose tissue thickness (normal and thicker). The computer model was validated based on data recorded by computer-controlled pressure-induced muscle pain in 8 and 16 partecipants, respectively. Results: The experimental pressure-indentation curve fitted the outcome of the FE model (R>0.73). Stress and strain were extracted from the models at a known painful pressure stimulation level. PPT and PPTO were not significantly different in subjects with normal and thick adipose tissue in accordance with the simulation model where the strain in muscle tissue was comparable in the two conditions. The strain in adipose tissue was larger in subjects with thick adipose tissue compared with normal adipose thickness. In relaxed muscle (hardness I) the principal strain peaked at 0.12 in the adipose tissue, was reduced to 0.07 in the muscle tissue and 0.05 in the harder muscle. Significantly higher PPT and PPTO were recorded in harder compared with softer muscles (P
KW - finite element model
KW - muscle hardness
KW - muscle pain
KW - pressure algometry
UR - http://www.scopus.com/inward/record.url?scp=79955832855&partnerID=8YFLogxK
U2 - 10.1097/AJP.0b013e31820c5353
DO - 10.1097/AJP.0b013e31820c5353
M3 - Journal article
C2 - 21415721
AN - SCOPUS:79955832855
SN - 0749-8047
VL - 27
SP - 414
EP - 424
JO - The Clinical Journal of Pain
JF - The Clinical Journal of Pain
IS - 5
ER -