TY - JOUR
T1 - Effects of marine n-3 fatty acid supplementation in renal transplantation
T2 - a randomized controlled trial
AU - Eide, Ivar A
AU - Reinholt, Finn P
AU - Jenssen, Trond
AU - Hartmann, Anders
AU - Schmidt, Erik B
AU - Åsberg, Anders
AU - Bergan, Stein
AU - Brabrand, Knut
AU - Svensson, My
N1 - © 2018 The American Society of Transplantation and the American Society of Transplant Surgeons.
PY - 2019/3
Y1 - 2019/3
N2 - Marine n-3 fatty acids (FAs) may exert beneficial effects on inflammation, fibrosis, and endothelial function, which could preserve renal graft function. In this randomized controlled trial, 132 Norwegian renal transplant recipients received either 2.6 g of marine n-3 FAs or olive oil (control) daily for 44 weeks, in addition to standard care. Thirty patients did not complete the trial. The primary endpoint was change (Δ) in measured glomerular filtration rate (mGFR) during follow-up. We found no significant difference in Δ mGFR between the marine n-3 FA group and controls (6.7 vs 3.8 mL/min/1.73 m2 , p=0.15). Significant beneficial effects from marine n-3 FA supplementation were, however, seen in secondary endpoints plasma triglycerides, plasma high-sensitivity C-reactive protein and brachial artery flow mediated dilation. In the per-protocol population, also the renal graft indices percent interstitial fibrosis and Chronic Allograft Damage Index were significantly lower in the marine n-3 FA group. The cumulative incidence of adverse events did not differ between the marine n-3 FA group (n=218) and controls (n=240). In conclusion, marine FA supplementation did not improve renal function compared with controls, but was safe, lowered plasma triglyceride and high-sensitivity C-reactive protein levels and improved endothelial function. This article is protected by copyright. All rights reserved.
AB - Marine n-3 fatty acids (FAs) may exert beneficial effects on inflammation, fibrosis, and endothelial function, which could preserve renal graft function. In this randomized controlled trial, 132 Norwegian renal transplant recipients received either 2.6 g of marine n-3 FAs or olive oil (control) daily for 44 weeks, in addition to standard care. Thirty patients did not complete the trial. The primary endpoint was change (Δ) in measured glomerular filtration rate (mGFR) during follow-up. We found no significant difference in Δ mGFR between the marine n-3 FA group and controls (6.7 vs 3.8 mL/min/1.73 m2 , p=0.15). Significant beneficial effects from marine n-3 FA supplementation were, however, seen in secondary endpoints plasma triglycerides, plasma high-sensitivity C-reactive protein and brachial artery flow mediated dilation. In the per-protocol population, also the renal graft indices percent interstitial fibrosis and Chronic Allograft Damage Index were significantly lower in the marine n-3 FA group. The cumulative incidence of adverse events did not differ between the marine n-3 FA group (n=218) and controls (n=240). In conclusion, marine FA supplementation did not improve renal function compared with controls, but was safe, lowered plasma triglyceride and high-sensitivity C-reactive protein levels and improved endothelial function. This article is protected by copyright. All rights reserved.
KW - clinical research/practice
KW - interstitial fibrosis and tubular atrophy
KW - kidney (allograft) function/dysfunction
KW - kidney transplantation/nephrology
KW - nutrition
KW - pathology/histopathology
KW - vascular biology
UR - http://www.scopus.com/inward/record.url?scp=85053694497&partnerID=8YFLogxK
U2 - 10.1111/ajt.15080
DO - 10.1111/ajt.15080
M3 - Journal article
C2 - 30125457
SN - 1600-6135
VL - 19
SP - 790
EP - 800
JO - American Journal of Transplantation
JF - American Journal of Transplantation
IS - 3
ER -