TY - GEN
T1 - Evaluation of Rate of Muscular Force Development in Type 2 Diabetic Individuals with and without Diabetic Peripheral Neuropathy
AU - Favretto, M. A.
AU - Cossul, S.
AU - Andreis, F. R.
AU - Marques, J. L. B.
PY - 2019
Y1 - 2019
N2 - Diabetic peripheral neuropathy (DPN) has been associated with motor dysfunctions, such as reduction in the maximum force of ankle dorsiflexion and muscle atrophy in the lower limbs. These changes contribute to functional limitations, such as changes in gait. The rate of muscular force development (RFD) is derived from the force-time curve obtained during a maximal voluntary isometric contraction (MVIC), performed in a short period of time. RFD seems to be better related to gait changes and neuromuscular dysfunctions than the MVIC. Therefore, the purpose of this study was to evaluate alterations in the RFD in type 2 diabetic individuals with and without DPN. Twenty-two adults participated in the study, divided in three groups: control (n = 8), diabetic without DPN (n = 8) and diabetic with DPN (n = 7). The participants performed three MVIC of the ankle dorsiflexion. To the analysis of the force-time curve, it was selected the highest of the three MVICs obtained. The force-time curve was normalized by the peak value of MVIC. RFD was derived as the slope of the force-time normalized curve over the 0–50% and 0–100% force ranges of the MVIC. The area and time to achieve this ranges were also calculated. The MVIC force was significantly lower (p < 0.05) for the group with DPN (187.78 ± 71.70 N) when compared to the control group (275.77 ± 88.13 N). The RFD(0–50%) was significantly lower (p < 0.05) for the group with DPN (115 ± 44% MVIC/s) in relation to the control group (233 ± 102% MVIC/s). The RFD(0–100%) was significantly lower (p < 0.05) for the groups without DPN (64 ± 22% MVIC/s) and with DPN (61 ± 24% MVIC/s) when compared to the control group (114 ± 45% MVIC/s). We conclude that these alterations may be related to muscle fiber atrophy, and loss of the motor unit caused by diabetes mellitus and DPN.
AB - Diabetic peripheral neuropathy (DPN) has been associated with motor dysfunctions, such as reduction in the maximum force of ankle dorsiflexion and muscle atrophy in the lower limbs. These changes contribute to functional limitations, such as changes in gait. The rate of muscular force development (RFD) is derived from the force-time curve obtained during a maximal voluntary isometric contraction (MVIC), performed in a short period of time. RFD seems to be better related to gait changes and neuromuscular dysfunctions than the MVIC. Therefore, the purpose of this study was to evaluate alterations in the RFD in type 2 diabetic individuals with and without DPN. Twenty-two adults participated in the study, divided in three groups: control (n = 8), diabetic without DPN (n = 8) and diabetic with DPN (n = 7). The participants performed three MVIC of the ankle dorsiflexion. To the analysis of the force-time curve, it was selected the highest of the three MVICs obtained. The force-time curve was normalized by the peak value of MVIC. RFD was derived as the slope of the force-time normalized curve over the 0–50% and 0–100% force ranges of the MVIC. The area and time to achieve this ranges were also calculated. The MVIC force was significantly lower (p < 0.05) for the group with DPN (187.78 ± 71.70 N) when compared to the control group (275.77 ± 88.13 N). The RFD(0–50%) was significantly lower (p < 0.05) for the group with DPN (115 ± 44% MVIC/s) in relation to the control group (233 ± 102% MVIC/s). The RFD(0–100%) was significantly lower (p < 0.05) for the groups without DPN (64 ± 22% MVIC/s) and with DPN (61 ± 24% MVIC/s) when compared to the control group (114 ± 45% MVIC/s). We conclude that these alterations may be related to muscle fiber atrophy, and loss of the motor unit caused by diabetes mellitus and DPN.
KW - Diabetes mellitus
KW - Diabetic peripheral neuropathy
KW - Maximal voluntary isometric contractions
KW - Rate of muscular force development
UR - http://www.scopus.com/inward/record.url?scp=85067578641&partnerID=8YFLogxK
U2 - 10.1007/978-981-13-2119-1_5
DO - 10.1007/978-981-13-2119-1_5
M3 - Article in proceeding
SN - 978-981-13-2118-4
VL - 1
T3 - International Federation for Medical and Biological Engineering Proceedings
SP - 31
EP - 36
BT - XXIV Brazilian Congress on Biomedical Engineering
A2 - Costa-Felix, Rodrigo
A2 - Alvarenga, André Victor
A2 - Machado, João Carlos
PB - Springer
T2 - 26th Brazilian Congress on Biomedical Engineering
Y2 - 21 October 2018 through 25 October 2018
ER -