TY - JOUR
T1 - Extremely Preterm Infant Admissions Within the SafeBoosC-III Consortium During the COVID-19 Lockdown
AU - Rasmussen, Marie Isabel
AU - Hansen, Mathias Lühr
AU - Pichler, Gerhard
AU - Dempsey, Eugene
AU - Pellicer, Adelina
AU - El-Khuffash, Afif
AU - A, Shashidhar
AU - Piris-Borregas, Salvador
AU - Alsina, Miguel
AU - Cetinkaya, Merih
AU - Chalak, Lina
AU - Özkan, Hilal
AU - Baserga, Mariana
AU - Sirc, Jan
AU - Fuchs, Hans
AU - Ergenekon, Ebru
AU - Arruza, Luis
AU - Mathur, Amit
AU - Stocker, Martin
AU - Otero Vaccarello, Olalla
AU - Szczapa, Tomasz
AU - Sarafidis, Kosmas
AU - Królak-Olejnik, Barbara
AU - Memisoglu, Asli
AU - Reigstad, Hallvard
AU - Rafińska-Ważny, Elżbieta
AU - Hatzidaki, Eleftheria
AU - Peng, Zhang
AU - Gkentzi, Despoina
AU - Viellevoye, Renaud
AU - De Buyst, Julie
AU - Mastretta, Emmanuele
AU - Wang, Ping
AU - Hahn, Gitte Holst
AU - Bender, Lars
AU - Cornette, Luc
AU - Tkaczyk, Jakub
AU - Del Rio, Ruth
AU - Fumagalli, Monica
AU - Papathoma, Evangelia
AU - Wilinska, Maria
AU - Naulaers, Gunnar
AU - Sadowska-Krawczenko, Iwona
AU - Lecart, Chantal
AU - Couce, María Luz
AU - Fredly, Siv
AU - Heuchan, Anne Marie
AU - Karen, Tanja
AU - Greisen, Gorm
N1 - Copyright © 2021 Rasmussen, Hansen, Pichler, Dempsey, Pellicer, EL-Khuffash, A, Piris-Borregas, Alsina, Cetinkaya, Chalak, Özkan, Baserga, Sirc, Fuchs, Ergenekon, Arruza, Mathur, Stocker, Otero Vaccarello, Szczapa, Sarafidis, Królak-Olejnik, Memisoglu, Reigstad, Rafińska-Ważny, Hatzidaki, Peng, Gkentzi, Viellevoye, De Buyst, Mastretta, Wang, Hahn, Bender, Cornette, Tkaczyk, del Rio, Fumagalli, Papathoma, Wilinska, Naulaers, Sadowska-Krawczenko, Lecart, Couce, Fredly, Heuchan, Karen and Greisen.
PY - 2021
Y1 - 2021
N2 - Objective: To evaluate if the number of admitted extremely preterm (EP) infants (born before 28 weeks of gestational age) differed in the neonatal intensive care units (NICUs) of the SafeBoosC-III consortium during the global lockdown when compared to the corresponding time period in 2019. Design: This is a retrospective, observational study. Forty-six out of 79 NICUs (58%) from 17 countries participated. Principal investigators were asked to report the following information: (1) Total number of EP infant admissions to their NICU in the 3 months where the lockdown restrictions were most rigorous during the first phase of the COVID-19 pandemic, (2) Similar EP infant admissions in the corresponding 3 months of 2019, (3) the level of local restrictions during the lockdown period, and (4) the local impact of the COVID-19 lockdown on the everyday life of a pregnant woman. Results: The number of EP infant admissions during the first wave of the COVID-19 pandemic was 428 compared to 457 in the corresponding 3 months in 2019 (-6.6%, 95% CI -18.2 to +7.1%, p = 0.33). There were no statistically significant differences within individual geographic regions and no significant association between the level of lockdown restrictions and difference in the number of EP infant admissions. A post-hoc analysis based on data from the 46 NICUs found a decrease of 10.3%in the total number of NICU admissions (n = 7,499 in 2020 vs. n = 8,362 in 2019). Conclusion: This ad hoc study did not confirm previous reports of a major reduction in the number of extremely pretermbirths during the first phase of the COVID-19 pandemic. Clinical Trial Registration: ClinicalTrial.gov, identifier: NCT04527601 (registered August 26, 2020), https://clinicaltrials.gov/ct2/show/NCT04527601.
AB - Objective: To evaluate if the number of admitted extremely preterm (EP) infants (born before 28 weeks of gestational age) differed in the neonatal intensive care units (NICUs) of the SafeBoosC-III consortium during the global lockdown when compared to the corresponding time period in 2019. Design: This is a retrospective, observational study. Forty-six out of 79 NICUs (58%) from 17 countries participated. Principal investigators were asked to report the following information: (1) Total number of EP infant admissions to their NICU in the 3 months where the lockdown restrictions were most rigorous during the first phase of the COVID-19 pandemic, (2) Similar EP infant admissions in the corresponding 3 months of 2019, (3) the level of local restrictions during the lockdown period, and (4) the local impact of the COVID-19 lockdown on the everyday life of a pregnant woman. Results: The number of EP infant admissions during the first wave of the COVID-19 pandemic was 428 compared to 457 in the corresponding 3 months in 2019 (-6.6%, 95% CI -18.2 to +7.1%, p = 0.33). There were no statistically significant differences within individual geographic regions and no significant association between the level of lockdown restrictions and difference in the number of EP infant admissions. A post-hoc analysis based on data from the 46 NICUs found a decrease of 10.3%in the total number of NICU admissions (n = 7,499 in 2020 vs. n = 8,362 in 2019). Conclusion: This ad hoc study did not confirm previous reports of a major reduction in the number of extremely pretermbirths during the first phase of the COVID-19 pandemic. Clinical Trial Registration: ClinicalTrial.gov, identifier: NCT04527601 (registered August 26, 2020), https://clinicaltrials.gov/ct2/show/NCT04527601.
KW - COVID-19
KW - extremely preterm
KW - neonatal intensive care unit admission
KW - observational study
KW - pandemic
KW - randomized clinical trial
UR - http://www.scopus.com/inward/record.url?scp=85111256604&partnerID=8YFLogxK
U2 - 10.3389/fped.2021.647880
DO - 10.3389/fped.2021.647880
M3 - Journal article
C2 - 34322460
SN - 2296-2360
VL - 9
JO - Frontiers in Pediatrics
JF - Frontiers in Pediatrics
M1 - 647880
ER -