Facile one-pot reduction of β-nitrostyrenes to phenethylamines using sodium borohydride and copper(II) chloride

Laura d'Andrea; Simon Jademyr

doi:10.3762/bjoc.21.4

Facile one-pot reduction of β-nitrostyrenes to phenethylamines using sodium borohydride and copper(II) chloride

Laura d'Andrea^*, Simon Jademyr

^*Kontaktforfatter

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Formidling

Abstract

Phenethylamines and phenylisopropylamines of scientific relevance can be prepared with a NaBH4/CuCl2 system in 10 to 30 minutes via reduction of substituted β-nitrostyrenes. This one-pot procedure allows the quick isolation of substituted β-nitrostyrene scaffolds with 62–83% yield under mild conditions, without the need for special precautions, inert atmosphere, and time-consuming purification techniques.

Originalsprog	Engelsk
Tidsskrift	Beilstein Journal of Organic Chemistry
Vol/bind	21
Sider (fra-til)	39-46
Antal sider	8
ISSN	2195-951X
DOI	https://doi.org/10.3762/bjoc.21.4
Status	Udgivet - 7 jan. 2025

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10.3762/bjoc.21.4

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title = "Facile one-pot reduction of β-nitrostyrenes to phenethylamines using sodium borohydride and copper(II) chloride",

abstract = "Phenethylamines and phenylisopropylamines of scientific relevance can be prepared with a NaBH4/CuCl2 system in 10 to 30 minutes via reduction of substituted β-nitrostyrenes. This one-pot procedure allows the quick isolation of substituted β-nitrostyrene scaffolds with 62–83% yield under mild conditions, without the need for special precautions, inert atmosphere, and time-consuming purification techniques.",

keywords = "2C-X, CuCl2, NaBH4, phenethylamine, β-nitrostyrene",

author = "Laura d'Andrea and Simon Jademyr",

note = "Copyright {\textcopyright} 2025, D{\textquoteright}Andrea and Jademyr.",

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language = "English",

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T1 - Facile one-pot reduction of β-nitrostyrenes to phenethylamines using sodium borohydride and copper(II) chloride

AU - d'Andrea, Laura

AU - Jademyr, Simon

PY - 2025/1/7

Y1 - 2025/1/7

N2 - Phenethylamines and phenylisopropylamines of scientific relevance can be prepared with a NaBH4/CuCl2 system in 10 to 30 minutes via reduction of substituted β-nitrostyrenes. This one-pot procedure allows the quick isolation of substituted β-nitrostyrene scaffolds with 62–83% yield under mild conditions, without the need for special precautions, inert atmosphere, and time-consuming purification techniques.

AB - Phenethylamines and phenylisopropylamines of scientific relevance can be prepared with a NaBH4/CuCl2 system in 10 to 30 minutes via reduction of substituted β-nitrostyrenes. This one-pot procedure allows the quick isolation of substituted β-nitrostyrene scaffolds with 62–83% yield under mild conditions, without the need for special precautions, inert atmosphere, and time-consuming purification techniques.

KW - 2C-X

KW - CuCl2

KW - NaBH4

KW - phenethylamine

KW - β-nitrostyrene

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U2 - 10.3762/bjoc.21.4

DO - 10.3762/bjoc.21.4

M3 - Journal article

C2 - 39811686

SN - 2195-951X

VL - 21

SP - 39

EP - 46

JO - Beilstein Journal of Organic Chemistry

JF - Beilstein Journal of Organic Chemistry

ER -

Facile one-pot reduction of β-nitrostyrenes to phenethylamines using sodium borohydride and copper(II) chloride

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