Factors predicting kidney damage in Puumala virus infected patients in Southern Denmark

S Skarphedinsson, H C Thiesson, S A Shakar, M Tepel

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Abstract

In Europe, infections with Puumala hantavirus cause nephropathia epidemica. Presently the risk factors predicting severe kidney damage after Puumala virus infection are not well known. The objective of the study was to investigate environmental and individual factors predicting severe kidney damage caused by serologically established Puumala infections. In a nationwide cohort study we investigated all serologically established Puumala infections in Southern Denmark from 1996 to 2012. A total of 184 patients had serologically verified Puumala virus infection. In patients with Puumala virus infections the decrease of platelet counts preceded acute kidney failure. Multivariable logistic regression demonstrated that recent activities in the forest, platelet counts, and flu-like symptoms predicted estimated glomerular filtration rates less than 30 mL/min/1.73 m², but not age, gender, fever, nor abdominal pain. Severe kidney damage in Puumala infections in Southern Denmark is associated with the risk of recent activities in the forest.

OriginalsprogEngelsk
TidsskriftEuropean Journal of Clinical Microbiology & Infectious Diseases
Vol/bind34
Udgave nummer10
Sider (fra-til)2017-21
Antal sider5
ISSN0934-9723
DOI
StatusUdgivet - 2015

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