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Resumé

Diet, with its content of various types of fatty acids (FAs), is of great importance for cellular function. Adipose tissue (AT) serves as a storage for dietary FAs, but after appropriate activation it may also offer important biological properties, e.g., by releasing adipokines and cytokines to the surrounding milieu. Such effects may depend on the diet and type of FA involved. Similarly, the composition of FAs in the heart is also likely to be important for cardiac function. We investigated samples of epicardial adipose tissue (EAT), pericardial adipose tissue (PAT), subcutaneous adipose tissue (SCAT), and tissue from the right atrial appendage to compare the FA compositions in patients undergoing elective cardiac surgery. Minor differences among AT compartments were found, while the comparison of atrial tissue and EAT showed major differences in saturated fatty acids (SFAs), monounsaturated fatty acids (MUFAs), and n-3 and n-6 polyunsaturated fatty acids (PUFAs). These findings may be of importance for understanding biological availability, dietary effects, and the effects of FAs on the heart.
OriginalsprogEngelsk
Artikelnummer1506
TidsskriftNutrients
Vol/bind10
Udgave nummer10
Sider (fra-til)1-10
Antal sider10
ISSN2072-6643
DOI
StatusUdgivet - 15 okt. 2018

Citer dette

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title = "Fatty Acid Composition in Various Types of Cardiac Adipose Tissues and Its Relation to the Fatty Acid Content of Atrial Tissue",
abstract = "Diet, with its content of various types of fatty acids (FAs), is of great importance for cellular function. Adipose tissue (AT) serves as a storage for dietary FAs, but after appropriate activation it may also offer important biological properties, e.g., by releasing adipokines and cytokines to the surrounding milieu. Such effects may depend on the diet and type of FA involved. Similarly, the composition of FAs in the heart is also likely to be important for cardiac function. We investigated samples of epicardial adipose tissue (EAT), pericardial adipose tissue (PAT), subcutaneous adipose tissue (SCAT), and tissue from the right atrial appendage to compare the FA compositions in patients undergoing elective cardiac surgery. Minor differences among AT compartments were found, while the comparison of atrial tissue and EAT showed major differences in saturated fatty acids (SFAs), monounsaturated fatty acids (MUFAs), and n-3 and n-6 polyunsaturated fatty acids (PUFAs). These findings may be of importance for understanding biological availability, dietary effects, and the effects of FAs on the heart.",
keywords = "Adipose tissue, Atrial tissue, Diet, Epicardial adipose tissue, Fatty acids, Pericardial adipose tissue, Site-specific differences, Subcutaneous adipose tissue",
author = "Katrin Hjelmgaard and Eschen, {Rikke B.} and Schmidt, {Erik B.} and Andreasen, {Jan J.} and S{\o}ren Lundbye-Christensen",
year = "2018",
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TY - JOUR

T1 - Fatty Acid Composition in Various Types of Cardiac Adipose Tissues and Its Relation to the Fatty Acid Content of Atrial Tissue

AU - Hjelmgaard, Katrin

AU - Eschen, Rikke B.

AU - Schmidt, Erik B.

AU - Andreasen, Jan J.

AU - Lundbye-Christensen, Søren

PY - 2018/10/15

Y1 - 2018/10/15

N2 - Diet, with its content of various types of fatty acids (FAs), is of great importance for cellular function. Adipose tissue (AT) serves as a storage for dietary FAs, but after appropriate activation it may also offer important biological properties, e.g., by releasing adipokines and cytokines to the surrounding milieu. Such effects may depend on the diet and type of FA involved. Similarly, the composition of FAs in the heart is also likely to be important for cardiac function. We investigated samples of epicardial adipose tissue (EAT), pericardial adipose tissue (PAT), subcutaneous adipose tissue (SCAT), and tissue from the right atrial appendage to compare the FA compositions in patients undergoing elective cardiac surgery. Minor differences among AT compartments were found, while the comparison of atrial tissue and EAT showed major differences in saturated fatty acids (SFAs), monounsaturated fatty acids (MUFAs), and n-3 and n-6 polyunsaturated fatty acids (PUFAs). These findings may be of importance for understanding biological availability, dietary effects, and the effects of FAs on the heart.

AB - Diet, with its content of various types of fatty acids (FAs), is of great importance for cellular function. Adipose tissue (AT) serves as a storage for dietary FAs, but after appropriate activation it may also offer important biological properties, e.g., by releasing adipokines and cytokines to the surrounding milieu. Such effects may depend on the diet and type of FA involved. Similarly, the composition of FAs in the heart is also likely to be important for cardiac function. We investigated samples of epicardial adipose tissue (EAT), pericardial adipose tissue (PAT), subcutaneous adipose tissue (SCAT), and tissue from the right atrial appendage to compare the FA compositions in patients undergoing elective cardiac surgery. Minor differences among AT compartments were found, while the comparison of atrial tissue and EAT showed major differences in saturated fatty acids (SFAs), monounsaturated fatty acids (MUFAs), and n-3 and n-6 polyunsaturated fatty acids (PUFAs). These findings may be of importance for understanding biological availability, dietary effects, and the effects of FAs on the heart.

KW - Adipose tissue

KW - Atrial tissue

KW - Diet

KW - Epicardial adipose tissue

KW - Fatty acids

KW - Pericardial adipose tissue

KW - Site-specific differences

KW - Subcutaneous adipose tissue

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U2 - 10.3390/nu10101506

DO - 10.3390/nu10101506

M3 - Journal article

VL - 10

SP - 1

EP - 10

JO - Nutrients

JF - Nutrients

SN - 2072-6643

IS - 10

M1 - 1506

ER -