TY - JOUR
T1 - Fingolimod in pediatric multiple sclerosis
T2 - three case reports
AU - Ferilli, Michela Ada Noris
AU - Papetti, Laura
AU - Valeriani, Massimiliano
PY - 2021/5
Y1 - 2021/5
N2 - Treatment for pediatric-onset multiple sclerosis (POMS) currently reflects treatment for adult-onset MS, despite some differences in its clinical course. First-choice treatment of POMS generally consists of interferon β-1a or glatiramer acetate, with therapies such as natalizumab or fingolimod reserved for second-choice treatment. In cases of severe disease, both fingolimod and natalizumab can be considered first-choice therapy. This paper presents three case histories of patients with POMS and highlights the different uses of fingolimod within the POMS treatment algorithm. The first and third cases are examples of escalation therapy, both in females aged 16 to 17 years, with fingolimod administering as second choice following disease progression. The second case is an example of using fingolimod as first-choice therapy, given to a 12-year-old male with severe disease. In all three cases, over a period of approximately 1 year after the initiation of fingolimod treatment, there was no further disease progression and no adverse events were recorded.
AB - Treatment for pediatric-onset multiple sclerosis (POMS) currently reflects treatment for adult-onset MS, despite some differences in its clinical course. First-choice treatment of POMS generally consists of interferon β-1a or glatiramer acetate, with therapies such as natalizumab or fingolimod reserved for second-choice treatment. In cases of severe disease, both fingolimod and natalizumab can be considered first-choice therapy. This paper presents three case histories of patients with POMS and highlights the different uses of fingolimod within the POMS treatment algorithm. The first and third cases are examples of escalation therapy, both in females aged 16 to 17 years, with fingolimod administering as second choice following disease progression. The second case is an example of using fingolimod as first-choice therapy, given to a 12-year-old male with severe disease. In all three cases, over a period of approximately 1 year after the initiation of fingolimod treatment, there was no further disease progression and no adverse events were recorded.
KW - Fingolimod
KW - First-choice therapy
KW - Multiple sclerosis
KW - Pediatric patients
UR - http://www.scopus.com/inward/record.url?scp=85099753804&partnerID=8YFLogxK
U2 - 10.1007/s10072-021-05076-7
DO - 10.1007/s10072-021-05076-7
M3 - Journal article
C2 - 33483884
SN - 1590-1874
VL - 42
SP - 19
EP - 23
JO - Neurological Sciences
JF - Neurological Sciences
IS - Suppl 1
ER -