Frequency of HLA-B27 subtypes in a Danish population and in Danish patients with ankylosing spondylitis

John Bæch, Søren Schmidt Olsen, R Steffensen, K Varming, Niels Grunnet, C Jersild

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Abstract

Polymerase chain reaction in combination with sequence-specific oligonucleotide probes were used to analyze nine HLA-B27 subtypes among 51 healthy HLA-B27 positive Danish blood donors and 30 Danish HLA-B27 positive patients with ankylosing spondylitis (AS). In the group of healthy Danes we found two subtypes, B*2705 (90.2%) and B*2702 (9.8%), however, among the AS patients only the B*2705 subtype was detected. We did not find a significant evidence for associations between AS and a particular HLA-B27 subtype in a Danish population.

OriginalsprogEngelsk
TidsskriftHLA
Vol/bind49
Udgave nummer5
Sider (fra-til)499-502
Antal sider4
ISSN2059-2302
StatusUdgivet - maj 1997
Udgivet eksterntJa

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