Functional and structural neuroplastic changes related to sensitization proxies in patients with Osteoarthritis: a systematic review

P Pedersini*, M Gobbo, M D Bishop, L Arendt-Nielsen, J H Villafañe

*Kontaktforfatter

Publikation: Bidrag til tidsskriftReview (oversigtsartikel)peer review

4 Citationer (Scopus)
43 Downloads (Pure)

Abstract

Objective: Several reports in literature have identified sensitization as a possible basis for the enhanced pain reactions associated with osteoarthritis (OA). The aim of this current systematic review is to summarize functional and structural brain changes associated with surrogate sensitization parameters assessed in patients with OA-related pain. Design: Systematic review. Subjects: Patients with OA related pain. Methods: A literature search was conducted systematically in MEDLINE, CINAHL, EMBASE databases for human studies up to December 2019. Articles were included if they assessed brain imaging and sensitization parameters (quantitative sensory testing and questionnaires) in adults with OA-related pain. Methodological quality was assessed using the Methodological Index for Non-Randomized Studies (MINORS) score. Results: Five studies reporting on 138 patients were included in this review. The MINORS scale yielded mean scores of 8.5/16 and 12.3/24, for the cohort and case-control studies respectively. Four low-quality studies suggest a greater pain matrix activation associated with clinical measures of sensitization in patients with OA, while another study underlined the presence of structural changes (reduced gray matter volume) in the cortical areas involved in the nociceptive processing possible also related to sensitization. Conclusions: This review shows conflicting evidence for structural and functional neuroplastic brain changes related to sensitization proxies in patients with OA.

OriginalsprogEngelsk
TidsskriftPain Medicine
Vol/bind23
Udgave nummer3
Sider (fra-til)488–498
Antal sider11
ISSN1526-2375
DOI
StatusUdgivet - mar. 2022

Bibliografisk note

© The Author(s) 2021. Published by Oxford University Press on behalf of the American Academy of Pain Medicine. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

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