Fusaoctaxin A, an Example of a Two-Step Mechanism for Non-Ribosomal Peptide Assembly and Maturation in Fungi

Klaus Ringsborg Westphal, Katrine Amalie Hamborg Nielsen, Rasmus Dam Wollenberg, Mathias Bonde Møllerhøj, Simone Bachleitner, Lena Studt, Erik Lysøe, Henriette Giese, Reinhard Wimmer, Jens Laurids Sørensen, Teis Esben Sondergaard

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Abstract

Fungal non-ribosomal peptide synthetase (NRPS) clusters are spread across the chromosomes, where several modifying enzyme-encoding genes typically flank one NRPS. However, a recent study showed that the octapeptide fusaoctaxin A is tandemly synthesized by two NRPSs in Fusarium graminearum. Here, we illuminate parts of the biosynthetic route of fusaoctaxin A, which is cleaved into the tripeptide fusatrixin A and the pentapeptide fusapentaxin A during transport by a cluster-specific ABC transporter with peptidase activity. Further, we deleted the histone H3K27 methyltransferase kmt6, which induced the production of fusaoctaxin A.

OriginalsprogEngelsk
Artikelnummer277
TidsskriftToxins
Vol/bind11
Udgave nummer5
ISSN2072-6651
DOI
StatusUdgivet - 16 maj 2019

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