Gastrocolic Reflex Is Delayed and Diminished in Adults with Type 1 Diabetes

Anne-Marie Wegeberg, Donghua Liao, Sine L. Jensen, Peter S. Sørensen, Ida M. N. Wigh, Victoria S. Zaugg, Christina Brock*


Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

4 Citationer (Scopus)


BACKGROUND: Constipation is a prevalent gastrointestinal complication in diabetes. The pathophysiology may include neural dysfunction and impaired gastrocolic reflex; however, investigation of the latter has been limited in diabetes. Using the wireless motility capsule, we investigated whether the gastrocolic reflex was impaired in adults with type 1 diabetes compared to healthy.

METHODS: One hundred and four adults with type 1 diabetes underwent investigation with the wireless motility capsule and recorded sleep cycle, eating habits, and bowel movements in a diary. Colonic motility index, contraction amplitudes, time-to-peak, peak motility, and colonic transit time were investigated directly in response to a meal. Diagnosis of peripheral (nerve conduction) and autonomic (orthostatic hypotension) polyneuropathy was verified.

RESULTS: In comparison with health, people with diabetes had at the time of ingestion decreased motility index and contraction amplitudes (p < 0.001), prolonged time-to-peak (p = 0.01), and borderline decreased peak motility (p = 0.06), which taken together indicate impaired coordination of the gastrocolic reflex. These features were most prominent in those with concomitant peripheral or autonomic neuropathy. Additionally, they were associated with prolonged colonic transit time (p > 0.01).

CONCLUSIONS: In type 1 diabetes, the gastrocolic reflex was delayed and diminished and further associated with the presence of neuropathy and constipation. These results suggest that impaired reflex is part of the underlying pathogenesis in the development of constipation.

TidsskriftDigestive Diseases and Sciences
Udgave nummer10
Sider (fra-til)4827-4833
Antal sider7
StatusUdgivet - okt. 2022

Bibliografisk note

© 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.


Dyk ned i forskningsemnerne om 'Gastrocolic Reflex Is Delayed and Diminished in Adults with Type 1 Diabetes'. Sammen danner de et unikt fingeraftryk.