Gene-based Association Approach Identify Genes Across Stress Traits in Fruit Flies

Palle Duun Rohde, Stefan McKinnon Edwards, Pernille Merete Sarup, Peter Sørensen

Publikation: Konferencebidrag uden forlag/tidsskriftPaper uden forlag/tidsskriftForskningpeer review

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Abstrakt

Identification of genes explaining variation in quantitative traits or genetic risk factors of human diseases requires both good phenotypic- and genotypic data, but also efficient statistical methods. Genome-wide association studies may reveal association between phenotypic variation and variation at nucleotide level, thus potentially identify genetic variants. However, testing million of polymorphic nucleotide positions requires conservative correction for multiple testing which lowers the probability of finding genes with small to moderate effects. To alleviate this, we apply a gene based association approach grouping variants accordingly to gene position, thus lowering the number of statistical tests performed and increasing the probability of identifying genes with small to moderate effects. Using this approach we identify numerous genes associated with different types of stresses in Drosophila melanogaster, but also identify common genes that affects the stress traits.
OriginalsprogEngelsk
Publikationsdato18 aug. 2014
Antal sider3
StatusUdgivet - 18 aug. 2014
Udgivet eksterntJa
Begivenhed10th World Congress on Genetics Applied to Livestock Production (WCGALP) - The Westin Bayshore, 1601 Bayshore Drive, Vancouver, BC V6G 2V4, Vancouver, Canada
Varighed: 17 aug. 201422 aug. 2014
Konferencens nummer: 10th

Konference

Konference10th World Congress on Genetics Applied to Livestock Production (WCGALP)
Nummer10th
LokationThe Westin Bayshore, 1601 Bayshore Drive, Vancouver, BC V6G 2V4
LandCanada
ByVancouver
Periode17/08/201422/08/2014

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  • Citationsformater

    Rohde, P. D., Edwards, S. M., Sarup, P. M., & Sørensen, P. (2014). Gene-based Association Approach Identify Genes Across Stress Traits in Fruit Flies. Afhandling præsenteret på 10th World Congress on Genetics Applied to Livestock Production (WCGALP), Vancouver, Canada. https://asas.org/docs/default-source/wcgalp-posters/673_paper_9223_manuscript_493_0.pdf