TY - JOUR
T1 - Generation of eight human induced pluripotent stem cell lines from Parkinson's disease patients carrying familial mutations
AU - Chen, Muwan
AU - Maimaitili, Muyesier
AU - Buchholdt, Susanne Hvolbøl
AU - Jensen, Uffe Birk
AU - Febbraro, Fabia
AU - Denham, Mark
N1 - Copyright © 2019 The Authors. Published by Elsevier B.V. All rights reserved.
PY - 2020/1
Y1 - 2020/1
N2 - We generated eight induced pluripotent stem cell (iPSC) lines from Parkinson's disease (PD) patients with different familial mutations using non-integrating episomal plasmids. All iPSC lines have a normal karyotype, express pluripotent genes including POU5F1, NANOG, and show alkaline phosphatase activity, as well as the ability to differentiate into all three germ layers. These PD iPSC lines can be used for disease modeling to identify PD mechanisms and for the development or stratification of new drugs.
AB - We generated eight induced pluripotent stem cell (iPSC) lines from Parkinson's disease (PD) patients with different familial mutations using non-integrating episomal plasmids. All iPSC lines have a normal karyotype, express pluripotent genes including POU5F1, NANOG, and show alkaline phosphatase activity, as well as the ability to differentiate into all three germ layers. These PD iPSC lines can be used for disease modeling to identify PD mechanisms and for the development or stratification of new drugs.
UR - http://www.scopus.com/inward/record.url?scp=85075512851&partnerID=8YFLogxK
U2 - 10.1016/j.scr.2019.101657
DO - 10.1016/j.scr.2019.101657
M3 - Journal article
C2 - 31786474
SN - 1873-5061
VL - 42
JO - Stem Cell Research
JF - Stem Cell Research
M1 - 101657
ER -