Genomic variation predicts adaptive evolutionary responses better than population bottleneck history

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Abstrakt

The relationship between population size, inbreeding, loss of genetic variation and evolutionary potential of fitness traits is still unresolved, and large-scale empirical studies testing theoretical expectations are surprisingly scarce. Here we present a highly replicated experimental evolution setup with 120 lines of Drosophila melanogaster having experienced inbreeding caused by low population size for a variable number of generations. Genetic variation in inbred lines and in outbred control lines was assessed by genotyping-by-sequencing (GBS) of pooled samples consisting of 15 males per line. All lines were reared on a novel stressful medium for 10 generations during which body mass, productivity, and extinctions were scored in each generation. In addition, we investigated egg-to-adult viability in the benign and the stressful environments before and after rearing at the stressful conditions for 10 generations. We found strong positive correlations between levels of genetic variation and evolutionary response in all investigated traits, and showed that genomic variation was more informative in predicting evolutionary responses than population history reflected by expected inbreeding levels. We also found that lines with lower genetic diversity were at greater risk of extinction. For viability, the results suggested a trade-off in the costs of adapting to the stressful environments when tested in a benign environment. This work presents convincing support for long-standing evolutionary theory, and it provides novel insights into the association between genetic variation and evolutionary capacity in a gradient of diversity rather than dichotomous inbred/outbred groups.
OriginalsprogEngelsk
Artikelnummere1008205
TidsskriftPLOS Genetics
Vol/bind15
Udgave nummer6
Antal sider18
ISSN1553-7390
DOI
StatusUdgivet - 12 jun. 2019

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  • Aktiviteter

    • 2 Organisering af eller deltagelse i konference
    • 1 Konferenceoplæg
    • 1 Gæsteophold ved andre institutioner

    Experimental evolution and conservation: insights from Drosophila

    Michael Ørsted (Foredragsholder)

    5 apr. 2019

    Aktivitet: Foredrag og mundtlige bidragKonferenceoplæg

    Society for Molecular Biology and Evolutionary Biology

    Michael Ørsted (Deltager)

    3 jul. 20167 jul. 2016

    Aktivitet: Deltagelse i faglig begivenhedOrganisering af eller deltagelse i konference

    The University of Melbourne, Bio21 Institute

    Michael Ørsted (Gæsteforsker)

    15 maj 201616 nov. 2016

    Aktivitet: Gæsteophold ved andre institutioner

    Citationsformater