Aktiviteter pr. år
The relationship between population size, inbreeding, loss of genetic variation and evolutionary potential of fitness traits is still unresolved, and large-scale empirical studies testing theoretical expectations are surprisingly scarce. Here we present a highly replicated experimental evolution setup with 120 lines of Drosophila melanogaster having experienced inbreeding caused by low population size for a variable number of generations. Genetic variation in inbred lines and in outbred control lines was assessed by genotyping-by-sequencing (GBS) of pooled samples consisting of 15 males per line. All lines were reared on a novel stressful medium for 10 generations during which body mass, productivity, and extinctions were scored in each generation. In addition, we investigated egg-to-adult viability in the benign and the stressful environments before and after rearing at the stressful conditions for 10 generations. We found strong positive correlations between levels of genetic variation and evolutionary response in all investigated traits, and showed that genomic variation was more informative in predicting evolutionary responses than population history reflected by expected inbreeding levels. We also found that lines with lower genetic diversity were at greater risk of extinction. For viability, the results suggested a trade-off in the costs of adapting to the stressful environments when tested in a benign environment. This work presents convincing support for long-standing evolutionary theory, and it provides novel insights into the association between genetic variation and evolutionary capacity in a gradient of diversity rather than dichotomous inbred/outbred groups.
|Status||Udgivet - 12 jun. 2019|
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Experimental evolution and conservation: insights from Drosophila
Michael Ørsted (Foredragsholder)5 apr. 2019
Aktivitet: Foredrag og mundtlige bidrag › Konferenceoplæg
Society for Molecular Biology and Evolutionary Biology
Michael Ørsted (Deltager)3 jul. 2016 → 7 jul. 2016
Aktivitet: Deltagelse i faglig begivenhed › Organisering af eller deltagelse i konference
The University of Melbourne, Bio21 Institute
Michael Ørsted (Gæsteforsker)15 maj 2016 → 16 nov. 2016
Aktivitet: Gæsteophold ved andre institutioner
Inbreeding constrains host adaptive capacity and microbiome diversityØrsted, M., Yashiro, E., Hoffmann, A. A. & Kristensen, T. N., 16 aug. 2022.
Publikation: Konferencebidrag uden forlag/tidsskrift › Konferenceabstrakt til konference › Forskning › peer reviewÅben adgangFil
Population bottlenecks constrain host microbiome diversity and genetic variation impeding fitnessØrsted, M., Yashiro, E., Hoffmann, A. A. & Kristensen, T. N., 23 maj 2022, I: PLOS Genetics. 18, 5, s. e1010206
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer reviewÅben adgangFil