Abstract
Treatment of Graves' disease during pregnancy with antithyroid drugs (ATDs) poses a risk of inducing hypothyroidism and, thus, development of a goiter to the fetus. PATIENT FINDINGS: We report two patients referred to our department after discovery of a fetal goiter by ultrasound examination in the second trimester of pregnancy. The women receiving 400 mg/day propylthiouracil and 10 mg/day thiamizole, respectively, had thyrotropin and total thyroxine values within the normal reference range but a lowered free thyroxine level. Fetal blood sampling by cordocentesis revealed severe fetal hypothyroidism as the cause of goiter development. Reduction of maternal ATD dose and injection of levothyroxine intra-amniotically quickly reduced the goiter size, and both babies were born euthyroid and without goiters.
Originalsprog | Engelsk |
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Tidsskrift | Thyroid |
Vol/bind | 21 |
Sider (fra-til) | 75-81 |
Antal sider | 7 |
ISSN | 1050-7256 |
DOI | |
Status | Udgivet - 2011 |
Udgivet eksternt | Ja |