Greengenes2 unifies microbial data in a single reference tree

Daniel McDonald, Yueyu Jiang, Metin Balaban, Kalen Cantrell, Qiyun Zhu, Antonio Gonzalez, James T. Morton, Giorgia Nicolaou, Donovan H. Parks, Søren M. Karst, Mads Albertsen, Philip Hugenholtz, Todd DeSantis, Se Jin Song, Andrew Bartko, Aki S. Havulinna, Pekka Jousilahti, Susan Cheng, Michael Inouye, Teemu NiiranenMohit Jain, Veikko Salomaa, Leo Lahti, Siavash Mirarab, Rob Knight*

*Kontaktforfatter

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

97 Citationer (Scopus)

Abstract

Studies using 16S rRNA and shotgun metagenomics typically yield different results, usually attributed to PCR amplification biases. We introduce Greengenes2, a reference tree that unifies genomic and 16S rRNA databases in a consistent, integrated resource. By inserting sequences into a whole-genome phylogeny, we show that 16S rRNA and shotgun metagenomic data generated from the same samples agree in principal coordinates space, taxonomy and phenotype effect size when analyzed with the same tree.

OriginalsprogEngelsk
TidsskriftNature Biotechnology
Vol/bind42
Sider (fra-til)715–718
Antal sider4
ISSN1087-0156
DOI
StatusUdgivet - maj 2024

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© 2023. The Author(s).

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