Gut Microbiota in Bone Health and Diabetes

Julie Kristine Knudsen*, Peter Leutscher, Suzette Sørensen


Publikation: Bidrag til tidsskriftReview (oversigtsartikel)peer review

13 Citationer (Scopus)


Purpose of Review: Patients with diabetes mellitus (DM) are at increased risk of developing osteopathogenesis and skeletal fragility. The role of the gut microbiota in both DM and osteopathy is not fully explored and may be involved in the pathology of both diseases. Recent Findings: Gut microbiota alterations have been observed in DM and osteopathogenic disorders as compared with healthy controls, such as significantly lower abundance of Prevotella and higher abundance of Lactobacillus, with a diminished bacterial diversity. Other overlapping gastro-intestinal features include the loss of intestinal barrier function with translocation of bacterial metabolites to the blood stream, induction of immunological deficits and changes in hormonal and endocrinal signalling, which may lead to the development of diabetic osteopathy. Summary: Signalling pathways involved in both DM and osteopathy are affected by gut bacteria and their metabolites. Future studies should focus on gut microbiota involvement in both diseases.

TidsskriftCurrent Osteoporosis Reports
Udgave nummer4
Sider (fra-til)462-479
Antal sider18
StatusUdgivet - aug. 2021

Bibliografisk note

Korrektion udgivet:
Knudsen, J.K., Leutscher, P. & Sørensen, S. Correction to: Gut Microbiota in Bone Health and Diabetes. Curr Osteoporos Rep 19, 480 (2021).

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