Haptoglobin 2-2 Genotype, Patient, and Graft Survival in Renal Transplant Recipients

Laust Dupont, Ivar Anders Eide, Anders Hartmann, Jeppe Hagstrup Christensen, Anders Åsberg, Trond Jenssen, Henrik Krarup, My Svensson

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Abstrakt

Background: Cardiovascular disease is the leading cause of death in renal transplant recipients. An association between haptoglobin genotype 2-2 and cardiovascular disease has been found in patients with diabetes mellitus and liver transplant recipients. To date, the role of haptoglobin genotype after renal transplantation has not been studied. Methods: In this single-center retrospective cohort study of 1975 adult Norwegian transplant recipients, who underwent transplantation between 1999 and 2011, we estimated the risk of all-cause and cardiovascular mortality and overall and death-censored graft loss for patients with haptoglobin genotype 2-2 compared to genotype 2-1 or 1-1, after adjustment for confounders and competing risks. Results: We found no associations between haptoglobin genotype 2-2 and cardiovascular mortality (subdistributional hazard ratio 1.08, 95% confidence interval 0.78-1.49; P = .63). We also failed to detect any association between haptoglobin 2-2 genotype and all-cause mortality, overall graft loss, and death-censored graft loss. Similar results were found in the subpopulation of transplant recipients with diabetes. Conclusion: In this large cohort of kidney transplant recipients, we could not demonstrate any association between haptoglobin 2-2 genotype and patient or graft survival after renal transplantation.
OriginalsprogEngelsk
TidsskriftProgress in Transplantation
Vol/bind27
Udgave nummer4
Sider (fra-til)386-391
Antal sider6
ISSN1526-9248
DOI
StatusUdgivet - 2017

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