TY - JOUR
T1 - HbA1c, fasting and 2 h plasma glucose in current, ex- and never-smokers
T2 - a meta-analysis
AU - Soulimane, Soraya
AU - Simon, Dominique
AU - Herman, William H
AU - Lange, Celine
AU - Lee, Crystal M Y
AU - Colagiuri, Stephen
AU - Shaw, Jonathan E
AU - Zimmet, Paul Z
AU - Magliano, Dianna
AU - Ferreira, Sandra R G
AU - Dong, Yanghu
AU - Zhang, Lei
AU - Jorgensen, Torben
AU - Tuomilehto, Jaakko
AU - Mohan, Viswanathan
AU - Christensen, Dirk L
AU - Kaduka, Lydia
AU - Dekker, Jacqueline M
AU - Nijpels, Giel
AU - Stehouwer, Coen D A
AU - Lantieri, Olivier
AU - Fujimoto, Wilfred Y
AU - Leonetti, Donna L
AU - McNeely, Marguerite J
AU - Borch-Johnsen, Knut
AU - Boyko, Edward J
AU - Vistisen, Dorte
AU - Balkau, Beverley
AU - DETECT-2 Study Group
PY - 2014/1
Y1 - 2014/1
N2 - AIMS/HYPOTHESIS: The relationships between smoking and glycaemic variables have not been well explored. We compared HbA1c, fasting plasma glucose (FPG) and 2 h plasma glucose (2H-PG) in current, ex- and never-smokers.METHODS: This meta-analysis used individual data from 16,886 men and 18,539 women without known diabetes in 12 DETECT-2 consortium studies and in the French Data from an Epidemiological Study on the Insulin Resistance Syndrome (DESIR) and Telecom studies. Means of three glycaemic variables in current, ex- and never-smokers were modelled by linear regression, with study as a random factor. The I (2) statistic was used to evaluate heterogeneity among studies.RESULTS: HbA1c was 0.10% (95% CI 0.08, 0.12) (1.1 mmol/mol [0.9, 1.3]) higher in current smokers and 0.03% (0.01, 0.05) (0.3 mmol/mol [0.1, 0.5]) higher in ex-smokers, compared with never-smokers. For FPG, there was no significant difference between current and never-smokers (-0.004 mmol/l [-0.03, 0.02]) but FPG was higher in ex-smokers (0.12 mmol/l [0.09, 0.14]). In comparison with never-smokers, 2H-PG was lower (-0.44 mmol/l [-0.52, -0.37]) in current smokers, with no difference for ex-smokers (0.02 mmol/l [-0.06, 0.09]). There was a large and unexplained heterogeneity among studies, with I (2) always above 50%; I (2) was little changed after stratification by sex and adjustment for age and BMI. In this study population, current smokers had a prevalence of diabetes that was 1.30% higher as screened by HbA1c and 0.52% lower as screened by 2H-PG, in comparison with never-smokers.CONCLUSION/INTERPRETATION: Across this heterogeneous group of studies, current smokers had a higher HbA1c and lower 2H-PG than never-smokers. This will affect the chances of smokers being diagnosed with diabetes.
AB - AIMS/HYPOTHESIS: The relationships between smoking and glycaemic variables have not been well explored. We compared HbA1c, fasting plasma glucose (FPG) and 2 h plasma glucose (2H-PG) in current, ex- and never-smokers.METHODS: This meta-analysis used individual data from 16,886 men and 18,539 women without known diabetes in 12 DETECT-2 consortium studies and in the French Data from an Epidemiological Study on the Insulin Resistance Syndrome (DESIR) and Telecom studies. Means of three glycaemic variables in current, ex- and never-smokers were modelled by linear regression, with study as a random factor. The I (2) statistic was used to evaluate heterogeneity among studies.RESULTS: HbA1c was 0.10% (95% CI 0.08, 0.12) (1.1 mmol/mol [0.9, 1.3]) higher in current smokers and 0.03% (0.01, 0.05) (0.3 mmol/mol [0.1, 0.5]) higher in ex-smokers, compared with never-smokers. For FPG, there was no significant difference between current and never-smokers (-0.004 mmol/l [-0.03, 0.02]) but FPG was higher in ex-smokers (0.12 mmol/l [0.09, 0.14]). In comparison with never-smokers, 2H-PG was lower (-0.44 mmol/l [-0.52, -0.37]) in current smokers, with no difference for ex-smokers (0.02 mmol/l [-0.06, 0.09]). There was a large and unexplained heterogeneity among studies, with I (2) always above 50%; I (2) was little changed after stratification by sex and adjustment for age and BMI. In this study population, current smokers had a prevalence of diabetes that was 1.30% higher as screened by HbA1c and 0.52% lower as screened by 2H-PG, in comparison with never-smokers.CONCLUSION/INTERPRETATION: Across this heterogeneous group of studies, current smokers had a higher HbA1c and lower 2H-PG than never-smokers. This will affect the chances of smokers being diagnosed with diabetes.
KW - Blood Glucose
KW - Fasting
KW - Hemoglobin A, Glycosylated
KW - Humans
KW - Smoking
U2 - 10.1007/s00125-013-3058-y
DO - 10.1007/s00125-013-3058-y
M3 - Journal article
C2 - 24065153
SN - 0012-186X
VL - 57
SP - 30
EP - 39
JO - Diabetologia
JF - Diabetologia
IS - 1
ER -