TY - JOUR
T1 - Hepatitis B infection and vaccination coverage in men who have sex with men consulting a Danish venereal disease clinic
AU - Nielsen, Ulla Schierup
AU - Simonsen, Anne Birgitte
AU - Halkier-Sørensen, Lars
AU - Larsen, Carsten Schade
AU - Erikstrup, Christian
PY - 2015/8
Y1 - 2015/8
N2 - BACKGROUND: Vaccination guidelines from the Danish Health and Medicines Authority recommend vaccination of all men who have sex with men (MSM) against hepatitis B virus (HBV). The only existing data on HBV infection in Danish MSM stem from 1984: 58% of MSM attending venereal clinics in Copenhagen had a prior and 4% had a chronic HBV infection. The aim of this study was to provide up-to-date data on the prevalence of HBV infection and vaccination coverage among Danish MSM.METHODS: At the venereal clinic at Aarhus University Hospital, 1525 consecutive patients received a questionnaire covering risk group and vaccination status; moreover, HBV serology was performed. Prevalence proportions of serological signs of vaccination, infection, etc. were stratified according to self-reported risk group and vaccination status.RESULTS: In total, 141 patients were MSM. Among these, 14% (CI = 9-21%) were vaccinated, 7% (CI = 3-13%) had a prior infection and 1.4% (CI = 0.2-5%) were HBsAg positive. In patients recalling three doses of vaccination, 18% (CI = 11-26%) were anti-HBs negative and 0.8% (CI = 0.02-5%) were HBsAg positive. Similar data for other risk groups and the total clientele are presented.CONCLUSIONS: This study presents the first Scandinavian data on the prevalence of HBV infection and vaccination among MSM since the introduction of the vaccine. Danish health authorities should evaluate whether a carrier frequency of 1.4% and a vaccination coverage of 14% in MSM is acceptable or warrants intensified focus on vaccination. Prospective vaccination campaigns should consider prevaccination testing, since 18% of patients recalling three doses of vaccination were anti-HBs negative.
AB - BACKGROUND: Vaccination guidelines from the Danish Health and Medicines Authority recommend vaccination of all men who have sex with men (MSM) against hepatitis B virus (HBV). The only existing data on HBV infection in Danish MSM stem from 1984: 58% of MSM attending venereal clinics in Copenhagen had a prior and 4% had a chronic HBV infection. The aim of this study was to provide up-to-date data on the prevalence of HBV infection and vaccination coverage among Danish MSM.METHODS: At the venereal clinic at Aarhus University Hospital, 1525 consecutive patients received a questionnaire covering risk group and vaccination status; moreover, HBV serology was performed. Prevalence proportions of serological signs of vaccination, infection, etc. were stratified according to self-reported risk group and vaccination status.RESULTS: In total, 141 patients were MSM. Among these, 14% (CI = 9-21%) were vaccinated, 7% (CI = 3-13%) had a prior infection and 1.4% (CI = 0.2-5%) were HBsAg positive. In patients recalling three doses of vaccination, 18% (CI = 11-26%) were anti-HBs negative and 0.8% (CI = 0.02-5%) were HBsAg positive. Similar data for other risk groups and the total clientele are presented.CONCLUSIONS: This study presents the first Scandinavian data on the prevalence of HBV infection and vaccination among MSM since the introduction of the vaccine. Danish health authorities should evaluate whether a carrier frequency of 1.4% and a vaccination coverage of 14% in MSM is acceptable or warrants intensified focus on vaccination. Prospective vaccination campaigns should consider prevaccination testing, since 18% of patients recalling three doses of vaccination were anti-HBs negative.
KW - Adolescent
KW - Adult
KW - Aged
KW - Aged, 80 and over
KW - Ambulatory Care/statistics & numerical data
KW - Denmark/epidemiology
KW - Hepatitis B/epidemiology
KW - Hepatitis B Antibodies/blood
KW - Hepatitis B Vaccines
KW - Homeodomain Proteins
KW - Homosexuality, Male
KW - Humans
KW - Male
KW - Middle Aged
KW - Prevalence
KW - Prospective Studies
KW - Risk Factors
KW - Serologic Tests
KW - Sexually Transmitted Diseases/prevention & control
KW - Surveys and Questionnaires
KW - Vaccination/statistics & numerical data
KW - Young Adult
U2 - 10.3109/23744235.2015.1026932
DO - 10.3109/23744235.2015.1026932
M3 - Journal article
C2 - 25831259
SN - 2374-4235
VL - 47
SP - 517
EP - 522
JO - Infectious Diseases
JF - Infectious Diseases
IS - 8
ER -