Imaging, biomarker and invasive assessment of diffuse left ventricular myocardial fibrosis in atrial fibrillation

Gordon A Begg; Peter P Swoboda; Rashed Karim; Tobias Oesterlein; Kawal Rhode; Arun V Holden; John P Greenwood; Eduard Shantsila; Gregory Y H Lip; Sven Plein; Muzahir H Tayebjee

doi:10.1186/s12968-020-0603-y

Imaging, biomarker and invasive assessment of diffuse left ventricular myocardial fibrosis in atrial fibrillation

Gordon A Begg, Peter P Swoboda, Rashed Karim, Tobias Oesterlein, Kawal Rhode, Arun V Holden, John P Greenwood, Eduard Shantsila, Gregory Y H Lip, Sven Plein, Muzahir H Tayebjee

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

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Abstract

BACKGROUND: Using cardiovascular magnetic resonance imaging (CMR), it is possible to detect diffuse fibrosis of the left ventricle (LV) in patients with atrial fibrillation (AF), which may be independently associated with recurrence of AF after ablation. By conducting CMR, clinical, electrophysiology and biomarker assessment we planned to investigate LV myocardial fibrosis in patients undergoing AF ablation.

METHODS: LV fibrosis was assessed by T1 mapping in 31 patients undergoing percutaneous ablation for AF. Galectin-3, coronary sinus type I collagen C terminal telopeptide (ICTP), and type III procollagen N terminal peptide were measured with ELISA. Comparison was made between groups above and below the median for LV extracellular volume fraction (ECV), followed by regression analysis.

RESULTS: On linear regression analysis LV ECV had significant associations with invasive left atrial pressure (Beta 0.49, P = 0.008) and coronary sinus ICTP (Beta 0.75, P < 0.001), which remained significant on multivariable regression.

CONCLUSION: LV fibrosis in patients with AF is associated with left atrial pressure and invasively measured levels of ICTP turnover biomarker.

Originalsprog	Engelsk
Artikelnummer	13
Tidsskrift	Journal of Cardiovascular Magnetic Resonance
Vol/bind	22
Udgave nummer	1
ISSN	1097-6647
DOI	https://doi.org/10.1186/s12968-020-0603-y
Status	Udgivet - feb. 2020

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10.1186/s12968-020-0603-yLicens: CC BY 4.0

Begg et al (2020) Imaging, biomarker and invasive assessment of diffuse left ventricular myocardial fibrosis in atrial fibrillationForlagets udgivne version, 600 KBLicens: CC BY 4.0

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Citationsformater

Begg, G. A., Swoboda, P. P., Karim, R., Oesterlein, T., Rhode, K., Holden, A. V., Greenwood, J. P., Shantsila, E., Lip, G. Y. H., Plein, S., & Tayebjee, M. H. (2020). Imaging, biomarker and invasive assessment of diffuse left ventricular myocardial fibrosis in atrial fibrillation. Journal of Cardiovascular Magnetic Resonance, 22(1), Artikel 13. https://doi.org/10.1186/s12968-020-0603-y

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title = "Imaging, biomarker and invasive assessment of diffuse left ventricular myocardial fibrosis in atrial fibrillation",

abstract = "BACKGROUND: Using cardiovascular magnetic resonance imaging (CMR), it is possible to detect diffuse fibrosis of the left ventricle (LV) in patients with atrial fibrillation (AF), which may be independently associated with recurrence of AF after ablation. By conducting CMR, clinical, electrophysiology and biomarker assessment we planned to investigate LV myocardial fibrosis in patients undergoing AF ablation.METHODS: LV fibrosis was assessed by T1 mapping in 31 patients undergoing percutaneous ablation for AF. Galectin-3, coronary sinus type I collagen C terminal telopeptide (ICTP), and type III procollagen N terminal peptide were measured with ELISA. Comparison was made between groups above and below the median for LV extracellular volume fraction (ECV), followed by regression analysis.RESULTS: On linear regression analysis LV ECV had significant associations with invasive left atrial pressure (Beta 0.49, P = 0.008) and coronary sinus ICTP (Beta 0.75, P < 0.001), which remained significant on multivariable regression.CONCLUSION: LV fibrosis in patients with AF is associated with left atrial pressure and invasively measured levels of ICTP turnover biomarker.",

keywords = "Atrial fibrillation, Biomarkers, Cardiovascular magnetic resonance imaging, Fibrosis, Voltage mapping",

author = "Begg, {Gordon A} and Swoboda, {Peter P} and Rashed Karim and Tobias Oesterlein and Kawal Rhode and Holden, {Arun V} and Greenwood, {John P} and Eduard Shantsila and Lip, {Gregory Y H} and Sven Plein and Tayebjee, {Muzahir H}",

year = "2020",

month = feb,

doi = "10.1186/s12968-020-0603-y",

language = "English",

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T1 - Imaging, biomarker and invasive assessment of diffuse left ventricular myocardial fibrosis in atrial fibrillation

AU - Begg, Gordon A

AU - Swoboda, Peter P

AU - Karim, Rashed

AU - Oesterlein, Tobias

AU - Rhode, Kawal

AU - Holden, Arun V

AU - Greenwood, John P

AU - Shantsila, Eduard

AU - Lip, Gregory Y H

AU - Plein, Sven

AU - Tayebjee, Muzahir H

PY - 2020/2

Y1 - 2020/2

N2 - BACKGROUND: Using cardiovascular magnetic resonance imaging (CMR), it is possible to detect diffuse fibrosis of the left ventricle (LV) in patients with atrial fibrillation (AF), which may be independently associated with recurrence of AF after ablation. By conducting CMR, clinical, electrophysiology and biomarker assessment we planned to investigate LV myocardial fibrosis in patients undergoing AF ablation.METHODS: LV fibrosis was assessed by T1 mapping in 31 patients undergoing percutaneous ablation for AF. Galectin-3, coronary sinus type I collagen C terminal telopeptide (ICTP), and type III procollagen N terminal peptide were measured with ELISA. Comparison was made between groups above and below the median for LV extracellular volume fraction (ECV), followed by regression analysis.RESULTS: On linear regression analysis LV ECV had significant associations with invasive left atrial pressure (Beta 0.49, P = 0.008) and coronary sinus ICTP (Beta 0.75, P < 0.001), which remained significant on multivariable regression.CONCLUSION: LV fibrosis in patients with AF is associated with left atrial pressure and invasively measured levels of ICTP turnover biomarker.

AB - BACKGROUND: Using cardiovascular magnetic resonance imaging (CMR), it is possible to detect diffuse fibrosis of the left ventricle (LV) in patients with atrial fibrillation (AF), which may be independently associated with recurrence of AF after ablation. By conducting CMR, clinical, electrophysiology and biomarker assessment we planned to investigate LV myocardial fibrosis in patients undergoing AF ablation.METHODS: LV fibrosis was assessed by T1 mapping in 31 patients undergoing percutaneous ablation for AF. Galectin-3, coronary sinus type I collagen C terminal telopeptide (ICTP), and type III procollagen N terminal peptide were measured with ELISA. Comparison was made between groups above and below the median for LV extracellular volume fraction (ECV), followed by regression analysis.RESULTS: On linear regression analysis LV ECV had significant associations with invasive left atrial pressure (Beta 0.49, P = 0.008) and coronary sinus ICTP (Beta 0.75, P < 0.001), which remained significant on multivariable regression.CONCLUSION: LV fibrosis in patients with AF is associated with left atrial pressure and invasively measured levels of ICTP turnover biomarker.

KW - Atrial fibrillation

KW - Biomarkers

KW - Cardiovascular magnetic resonance imaging

KW - Fibrosis

KW - Voltage mapping

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U2 - 10.1186/s12968-020-0603-y

DO - 10.1186/s12968-020-0603-y

M3 - Journal article

C2 - 32036784

SN - 1097-6647

VL - 22

JO - Journal of Cardiovascular Magnetic Resonance

JF - Journal of Cardiovascular Magnetic Resonance

IS - 1

M1 - 13

ER -

Imaging, biomarker and invasive assessment of diffuse left ventricular myocardial fibrosis in atrial fibrillation

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