@article{e3881994fab54b58b7282064cca35e62,
title = "Impact of comorbidity on survival of Danish prostate cancer patients, 1995-2006: a population-based cohort study",
abstract = "OBJECTIVES: The existence of comorbid diseases among men with newly diagnosed prostate cancer may affect prostate cancer prognosis. METHODS: We identified patients (n = 8114) with a first-time discharge diagnosis of prostate cancer from Danish hospitals between 1995 and 2006. We measured comorbidity using the Charlson Comorbidity Index. RESULTS: The number of patients doubled between 1995 and 2006. The proportion of patients with Charlson scores of 0 (no comorbidity) increased from 62\% to 63\% of total patients diagnosed, whereas the proportion of patients with Charlson scores of 1 to 2 (moderate comorbidity) decreased from 31\% to 29\%, and the proportion with Charlson scores of 3 or higher (severe comorbidity) increased from 106 to 227 (7\% to 8\%). Among patients with a Charlson score of 0, the 1-year survival rate improved from 79\% to 94\%; among patients with Charlson scores of 1 to 2, the 1-year survival rate increased from 68\% to 83\%; and in patients with a Charlson score of 3 or higher, this rate increased from 61\% to 69\%. Compared with patients with Charlson scores of 0, patients with scores of 1 to 2 had age-adjusted 1-year mortality rate ratios (MRRs) of 1.60 in 1995 to 1997, increasing to 2.67 in 2004 to 2006. For patients with Charlson scores of 3 or higher, the adjusted MRR increased from 3.11 in 1995 to 1997 to 5.08 in 2004 to 2006. CONCLUSIONS: Comorbidity was present in more than one-third of prostate cancer patients and was a negative prognostic factor. Although prostate cancer survival generally has improved in Denmark in recent years, no improvement was found among those with high levels of comorbidity.",
keywords = "Adult, Aged, Aged, 80 and over, Cohort Studies, Comorbidity, Denmark, Humans, Male, Medical Oncology, Middle Aged, Prognosis, Prostatic Neoplasms, Risk Factors, Treatment Outcome",
author = "Lars Lund and Michael Borre and Jacob Jacobsen and S{\o}rensen, \{Henrik Toft\} and Mette N{\o}rgaard",
year = "2008",
doi = "10.1016/j.urology.2007.12.018",
language = "English",
volume = "72",
pages = "1258--62",
journal = "Urology",
issn = "0932-2329",
publisher = "Springer",
}