TY - JOUR
T1 - Increased Mortality Among Persons Infected with Hepatitis C Virus
AU - Omland, Lars Haukali
AU - Jepsen, Peter
AU - Krarup, Henrik
AU - Schønning, Kristian
AU - Lind, Bent
AU - Kromann-Andersen, Hans
AU - Homburg, Keld Mikkelsen
AU - Christensen, Peer Brehm
AU - Sørensen, Henrik Toft
AU - Obel, Niels
AU - DANVIR Cohort Study, null
N1 - Copyright © 2010 AGA Institute. Published by Elsevier Inc. All rights reserved.
PY - 2011
Y1 - 2011
N2 - BACKGROUND & AIMS: The long-term mortality of patients infected with Hepatitis C virus (HCV) is not known; few studies have controlled for potential confounders, investigated how mortality changes with age at diagnosis and length of follow up, provided absolute risk estimates of death, or analyzed specific causes of death. METHODS: Using a Danish population, we compared mortality of a cohort of 10,991 HCV-infected patients with that of an age- and sex-matched cohort. Using regression analysis, we adjusted for municipality of residence, history of psychiatric illness, comorbidities, alcohol and drug abuse, and income. We analyzed causes of death and effects of HCV with age and length of follow up. RESULTS: HCV-infected patients had lower income and more comorbidities, psychiatric illnesses, and substance and alcohol abuse than the comparison cohort. The 10-year survival rate decreased from 84.1% among HCV-infected patients aged 20-29 years to 21.1% among those aged 70 years or older. The increased risk of in death among HCV-infected patients was more pronounced in the first year of follow up than in subsequent years and in the unadjusted than in the adjusted analysis. Starting in the 2nd year of follow up, HCV-infected patients aged 20-29 years had an 18.2-fold increased risk of death, whereas those that were 70 years or older had a 1.6-fold increased risk. Most deaths among younger patients were from unnatural causes and most deaths among patients 70 years or older were from non-liver related natural causes. CONCLUSIONS: HCV-infection is associated with increased mortality; younger patients (age 20-29 years) have increased risk of unnatural death.
AB - BACKGROUND & AIMS: The long-term mortality of patients infected with Hepatitis C virus (HCV) is not known; few studies have controlled for potential confounders, investigated how mortality changes with age at diagnosis and length of follow up, provided absolute risk estimates of death, or analyzed specific causes of death. METHODS: Using a Danish population, we compared mortality of a cohort of 10,991 HCV-infected patients with that of an age- and sex-matched cohort. Using regression analysis, we adjusted for municipality of residence, history of psychiatric illness, comorbidities, alcohol and drug abuse, and income. We analyzed causes of death and effects of HCV with age and length of follow up. RESULTS: HCV-infected patients had lower income and more comorbidities, psychiatric illnesses, and substance and alcohol abuse than the comparison cohort. The 10-year survival rate decreased from 84.1% among HCV-infected patients aged 20-29 years to 21.1% among those aged 70 years or older. The increased risk of in death among HCV-infected patients was more pronounced in the first year of follow up than in subsequent years and in the unadjusted than in the adjusted analysis. Starting in the 2nd year of follow up, HCV-infected patients aged 20-29 years had an 18.2-fold increased risk of death, whereas those that were 70 years or older had a 1.6-fold increased risk. Most deaths among younger patients were from unnatural causes and most deaths among patients 70 years or older were from non-liver related natural causes. CONCLUSIONS: HCV-infection is associated with increased mortality; younger patients (age 20-29 years) have increased risk of unnatural death.
U2 - 10.1016/j.cgh.2010.09.014
DO - 10.1016/j.cgh.2010.09.014
M3 - Journal article
SN - 1542-3565
VL - 9
SP - 71
EP - 78
JO - Clinical Gastroenterology and Hepatology
JF - Clinical Gastroenterology and Hepatology
ER -