TY - JOUR
T1 - Influence of fibrous encapsulation on electro-chemical properties of TiN electrodes
AU - Meijs, Suzan
AU - Fjorback, Morten
AU - Jensen, Carina
AU - Sørensen, Søren
AU - Rechendorff, Kristian
AU - Rijkhoff, Nico J. M.
N1 - Copyright © 2016 IPEM. Published by Elsevier Ltd. All rights reserved.
PY - 2016
Y1 - 2016
N2 - The aim of this study was to investigate how the electrochemical properties of porous titanium nitride stimulation electrode are affected by fibrous encapsulation in vivo. Electrochemical impedance spectroscopy (EIS), cyclic voltammetry and voltage transient (VT) measurements were performed in vivo and in phosphate buffered saline, where the encapsulation process is absent. EIS was used as a non-invasive measurement to follow the inflammation, healing and encapsulation process. EIS showed that the healing and encapsulation process lasted 3-4 weeks. The VTs increased during the first 3-4 weeks, after which they stabilized. The charge storage capacity (CSC) decreased most during the first 3-4 weeks. The increasing VTs and decreasing CSC during the first 3-4 weeks after implantation of the in vivo electrodes seem related to healing and fibrous encapsulation. It is suggested that the charge injection pathway during the encapsulation process changes, which implies that charge injection limits are underestimated with conventional methods.
AB - The aim of this study was to investigate how the electrochemical properties of porous titanium nitride stimulation electrode are affected by fibrous encapsulation in vivo. Electrochemical impedance spectroscopy (EIS), cyclic voltammetry and voltage transient (VT) measurements were performed in vivo and in phosphate buffered saline, where the encapsulation process is absent. EIS was used as a non-invasive measurement to follow the inflammation, healing and encapsulation process. EIS showed that the healing and encapsulation process lasted 3-4 weeks. The VTs increased during the first 3-4 weeks, after which they stabilized. The charge storage capacity (CSC) decreased most during the first 3-4 weeks. The increasing VTs and decreasing CSC during the first 3-4 weeks after implantation of the in vivo electrodes seem related to healing and fibrous encapsulation. It is suggested that the charge injection pathway during the encapsulation process changes, which implies that charge injection limits are underestimated with conventional methods.
UR - https://www.scopus.com/record/display.uri?eid=2-s2.0-84977939773&origin=inward&txGid=03EB75B4FE440F5A345F107F454ED6B1.wsnAw8kcdt7IPYLO0V48gA%3a1#
U2 - 10.1016/j.medengphy.2016.02.010
DO - 10.1016/j.medengphy.2016.02.010
M3 - Journal article
C2 - 26997562
SN - 1350-4533
VL - 38
SP - 468
EP - 476
JO - Medical Engineering & Physics
JF - Medical Engineering & Physics
IS - 5
ER -