Inhibition of mRNA translation extends lifespan in Caenorhabditis elegans

Kally Z Pan, Julia E Palter, Aric N Rogers, Anders Olsen, Di Chen, Gordon J Lithgow, Pankaj Kapahi

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

385 Citationer (Scopus)

Abstrakt

Protein synthesis is a regulated cellular process that links nutrients in the environment to organismal growth and development. Here we examine the role of genes that regulate mRNA translation in determining growth, reproduction, stress resistance and lifespan. Translational control of protein synthesis by regulators such as the cap-binding complex and S6 kinase play an important role during growth. We observe that inhibition of various genes in the translation initiation complex including ifg-1, the worm homologue of eIF4G, which is a scaffold protein in the cap-binding complex; and rsks-1, the worm homologue of S6 kinase, results in lifespan extension in Caenorhabditis elegans. Inhibition of ifg-1 or rsks-1 also slows development, reduces fecundity and increases resistance to starvation. A reduction in ifg-1 expression in dauers was also observed, suggesting an inhibition of protein translation during the dauer state. Thus, mRNA translation exerts pleiotropic effects on growth, reproduction, stress resistance and lifespan in C. elegans.

OriginalsprogEngelsk
TidsskriftAging Cell
Vol/bind6
Udgave nummer1
Sider (fra-til)111-9
Antal sider9
ISSN1474-9718
DOI
StatusUdgivet - feb. 2007
Udgivet eksterntJa

Fingeraftryk

Dyk ned i forskningsemnerne om 'Inhibition of mRNA translation extends lifespan in Caenorhabditis elegans'. Sammen danner de et unikt fingeraftryk.

Citationsformater