Insulin-based infusion system: Advancing the development

N. Hashemi, T. Valk, K. Houlind, N. Ejskjær

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review


Background: Deviations in glucose control in critical care have been shown to increase mortality and morbidity. However, optimal glucose control through present technologies has shown to be a challenge. The insulin balanced infusion system (IBIS) is a new and emerging technology. Methods: The closed loop system was tested in a stress trial to evaluate glucose stability in response to various conditions in nonrandomized people with type 1 diabetes mellitus (n=12). The prototype used in this trial was based on intermittent capillary measurements. Results: Induced stresses in the study using unpredicted stimuli of intravenous or oral glucose and intravenous insulin boluses, was contained with glucose remaining in target 43.8% of the time. Mean increase in glucose concentration after glucose load was 17.4 mg/dl; after insulin bolus, no hypoglycemia (blood glucose less than 70 mg/dl) occurred. Conclusion: The use of IBIS proved safe and feasible under a wide range of conditions. The sensing and stress response of the IBIS demonstrated noticeable features.

TidsskriftJournal of Diabetes Science and Technology
Udgave nummer5
Sider (fra-til)941-948
Antal sider8
StatusUdgivet - 1 sep. 2019

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