TY - JOUR
T1 - Insulin-based infusion system
T2 - Advancing the development
AU - Hashemi, N.
AU - Valk, T.
AU - Houlind, K.
AU - Ejskjær, N.
PY - 2019/9/1
Y1 - 2019/9/1
N2 - Background: Deviations in glucose control in critical care have been shown to increase mortality and morbidity. However, optimal glucose control through present technologies has shown to be a challenge. The insulin balanced infusion system (IBIS) is a new and emerging technology. Methods: The closed loop system was tested in a stress trial to evaluate glucose stability in response to various conditions in nonrandomized people with type 1 diabetes mellitus (n=12). The prototype used in this trial was based on intermittent capillary measurements. Results: Induced stresses in the study using unpredicted stimuli of intravenous or oral glucose and intravenous insulin boluses, was contained with glucose remaining in target 43.8% of the time. Mean increase in glucose concentration after glucose load was 17.4 mg/dl; after insulin bolus, no hypoglycemia (blood glucose less than 70 mg/dl) occurred. Conclusion: The use of IBIS proved safe and feasible under a wide range of conditions. The sensing and stress response of the IBIS demonstrated noticeable features.
AB - Background: Deviations in glucose control in critical care have been shown to increase mortality and morbidity. However, optimal glucose control through present technologies has shown to be a challenge. The insulin balanced infusion system (IBIS) is a new and emerging technology. Methods: The closed loop system was tested in a stress trial to evaluate glucose stability in response to various conditions in nonrandomized people with type 1 diabetes mellitus (n=12). The prototype used in this trial was based on intermittent capillary measurements. Results: Induced stresses in the study using unpredicted stimuli of intravenous or oral glucose and intravenous insulin boluses, was contained with glucose remaining in target 43.8% of the time. Mean increase in glucose concentration after glucose load was 17.4 mg/dl; after insulin bolus, no hypoglycemia (blood glucose less than 70 mg/dl) occurred. Conclusion: The use of IBIS proved safe and feasible under a wide range of conditions. The sensing and stress response of the IBIS demonstrated noticeable features.
KW - automated glucose monitoring
KW - closed loop glucose control
KW - critical care glucose control
KW - stress trial
UR - http://www.scopus.com/inward/record.url?scp=85062860338&partnerID=8YFLogxK
U2 - 10.1177/1932296819832876
DO - 10.1177/1932296819832876
M3 - Journal article
SN - 1932-2968
VL - 13
SP - 941
EP - 948
JO - Journal of Diabetes Science and Technology
JF - Journal of Diabetes Science and Technology
IS - 5
ER -