TY - JOUR
T1 - Interaction between obesity and the NFKB1 - 94ins/delATTG promoter polymorphism in relation to incident acute coronary syndrome
T2 - A follow up study in three independent cohorts
AU - Stegger, Jakob Gerhard
AU - Schmidt, Erik Berg
AU - Berentzen, Tina Landsvig
AU - Tjønneland, Anne
AU - Vogel, Ulla Birgitte
AU - Rimm, Eric
AU - Sørensen, Thorkild I A
AU - Overvad, Kim
AU - Jensen, Majken K
PY - 2013/5/9
Y1 - 2013/5/9
N2 - The NF-κB transcription factor family regulates several genes encoding pro-inflammatory and anti-inflammatory proteins in adipose tissues and in atherosclerotic plaques. The deletion variant allele of the NFKB1 - 94ins/delATTG promoter polymorphism leads to lower transcript levels of the p50 subunit, and the variant allele has been associated with the risk of several inflammatory diseases as well as coronary heart disease where inflammation is important in the pathogenesis. The objective of this study was to explore the potential interaction between the NFKB1-94ins/delATTG promoter polymorphism and general, abdominal, and gluteofemoral obesity in relation to the risk of incident acute coronary syndrome (ACS) in three large independent cohorts.
AB - The NF-κB transcription factor family regulates several genes encoding pro-inflammatory and anti-inflammatory proteins in adipose tissues and in atherosclerotic plaques. The deletion variant allele of the NFKB1 - 94ins/delATTG promoter polymorphism leads to lower transcript levels of the p50 subunit, and the variant allele has been associated with the risk of several inflammatory diseases as well as coronary heart disease where inflammation is important in the pathogenesis. The objective of this study was to explore the potential interaction between the NFKB1-94ins/delATTG promoter polymorphism and general, abdominal, and gluteofemoral obesity in relation to the risk of incident acute coronary syndrome (ACS) in three large independent cohorts.
U2 - 10.1371/journal.pone.0063004
DO - 10.1371/journal.pone.0063004
M3 - Journal article
C2 - 23671649
SN - 1932-6203
VL - 8
SP - e63004
JO - P L o S One
JF - P L o S One
IS - 5
ER -