TY - JOUR
T1 - Irreversible electroporation of pancreatic cancer - Effect on quality of life and pain perception
AU - Flak, Rasmus Virenfeldt
AU - Malmberg, Molly Maine
AU - Stender, Mogens Tornby
AU - Hauberg, Ann
AU - Thorlacius-Ussing, Ole
N1 - Copyright © 2021 IAP and EPC. Published by Elsevier B.V. All rights reserved.
PY - 2021/9
Y1 - 2021/9
N2 - BACKGROUND: Most pancreatic cancer (PC) patients are incurable and may need palliative treatment at some point in time. Irreversible electroporation (IRE) is a novel ablative treatment, which aims to provide local tumor control. The aim of this study was to examine how consolidative treatment with IRE affects quality of life (QOL) and pain perception (PP) in patients with non-metastatic pancreatic cancer.METHODS: Secondary outcomes were extracted from a prospective cohort of non-metastatic PC patients treated with IRE from 2013 to 2019. Patients filled in two questionnaires examining QOL and PP at different timepoints during treatment and follow-up. Data from a selected panel of subscales were extracted and analyzed using a mixed random intercept regression model.RESULTS: Subscales from 41 patients at four different timepoints were included in the model. Global health status, physical functioning, fatigue, nausea and vomiting, appetite loss and mean pain interference were negatively impacted (p < 0.05) in the short- and mid-term, corresponding to a low or moderate clinical effect size. However, all negative effects showed a tendency to dissipate over time.CONCLUSIONS: IRE treatment negatively impacted QOL and PP in the short- and mid-term. No positive long-term effects of IRE were found.
AB - BACKGROUND: Most pancreatic cancer (PC) patients are incurable and may need palliative treatment at some point in time. Irreversible electroporation (IRE) is a novel ablative treatment, which aims to provide local tumor control. The aim of this study was to examine how consolidative treatment with IRE affects quality of life (QOL) and pain perception (PP) in patients with non-metastatic pancreatic cancer.METHODS: Secondary outcomes were extracted from a prospective cohort of non-metastatic PC patients treated with IRE from 2013 to 2019. Patients filled in two questionnaires examining QOL and PP at different timepoints during treatment and follow-up. Data from a selected panel of subscales were extracted and analyzed using a mixed random intercept regression model.RESULTS: Subscales from 41 patients at four different timepoints were included in the model. Global health status, physical functioning, fatigue, nausea and vomiting, appetite loss and mean pain interference were negatively impacted (p < 0.05) in the short- and mid-term, corresponding to a low or moderate clinical effect size. However, all negative effects showed a tendency to dissipate over time.CONCLUSIONS: IRE treatment negatively impacted QOL and PP in the short- and mid-term. No positive long-term effects of IRE were found.
KW - Ablation techniques
KW - Electroporation
KW - Pain management
KW - Pancreatic neoplasms
KW - Quality of life
UR - http://www.scopus.com/inward/record.url?scp=85105576818&partnerID=8YFLogxK
U2 - 10.1016/j.pan.2021.04.011
DO - 10.1016/j.pan.2021.04.011
M3 - Journal article
C2 - 33985915
VL - 21
SP - 1059
EP - 1063
JO - Pancreatology
JF - Pancreatology
SN - 1424-3903
IS - 6
ER -