Abstract
Background: Obesity is a well-established risk factor for coronary heart disease (CHD). However, the influence of other lifestyle and clinical risk factors on the association between body-mass index (BMI: weight in kg/height in m2) and CHD remains uncertain. Methods and Results: In the Danish Diet, Cancer and Health study, we followed 29,262 women and 26,088 men, 50 to 64 years of age, who were free of acute coronary syndrome (ACS) and cancer at baseline in 1993-1997. During a mean follow-up of 8 years, we documented 262 female and 845 male cases of ACS. Lifestyle risk factors were categorized as current smoking, <30 min/week of sports activity, below the median for the Mediterranean diet score, and <8 years of education. Clinical risk factors included self-reported hypertension, hypercholesterolemia, and diabetes. Overweight (BMI>25 kg/m2) and obesity (BMI>30 kg/m2) were significantly associated with a higher risk of ACS, as were each of the individual lifestyle and clinical risk factors. Joint effects of obesity and each risk factor were close to additive. When all lifestyle factors were summed, obese individuals with the greatest number of lifestyle factors had the highest risk, but no synergism was observed. Similar results were seen for clinical risk factors. Of importance, a strong direct association between BMI and ACS was observed even among participants with the lowest number of other risk factors present. Conclusions: Our results illustrate that BMI is an important, independent predictor of ACS risk, even among individuals who have few CHD risk factors. BMI and other CHD risk factors appear to work in an additive fashion on risk of ACS.
Originalsprog | Engelsk |
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Publikationsdato | 2007 |
Antal sider | 1 |
Status | Udgivet - 2007 |
Begivenhed | Annual Conference on Cardiovascular Disease Epidemiology and Prevention - Orlando, FL, USA Varighed: 28 feb. 2007 → 3 mar. 2007 Konferencens nummer: 47 |
Konference
Konference | Annual Conference on Cardiovascular Disease Epidemiology and Prevention |
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Nummer | 47 |
Land/Område | USA |
By | Orlando, FL |
Periode | 28/02/2007 → 03/03/2007 |
Bibliografisk note
Titel på proceedings: Circulation, Vol. 115, Nr. 8Oversat titel på proceedings: Circulation