TY - JOUR
T1 - Levels of SARS-CoV-2 antibodies among fully vaccinated individuals with Delta or Omicron variant breakthrough infections
AU - Stærke, Nina Breinholt
AU - Reekie, Joanne
AU - Nielsen, Henrik
AU - Benfield, Thomas
AU - Wiese, Lothar
AU - Knudsen, Lene Surland
AU - Iversen, Mette Brouw
AU - Iversen, Kasper
AU - Fogh, Kamille
AU - Bodilsen, Jacob
AU - Juhl, Maria Ruwald
AU - Lindvig, Susan Olaf
AU - Øvrehus, Anne
AU - Madsen, Lone Wulff
AU - Klastrup, Vibeke
AU - Andersen, Sidsel Dahl
AU - Juhl, Anna Karina
AU - Andreasen, Signe Rode
AU - Ostrowski, Sisse Rye
AU - Erikstrup, Christian
AU - Fischer, Thea K
AU - Tolstrup, Martin
AU - Østergaard, Lars
AU - Johansen, Isik Somuncu
AU - Lundgren, Jens
AU - Søgaard, Ole Schmeltz
N1 - © 2022. The Author(s).
PY - 2022/12
Y1 - 2022/12
N2 - SARS-CoV-2 variants of concern have continuously evolved and may erode vaccine induced immunity. In this observational cohort study, we determine the risk of breakthrough infection in a fully vaccinated cohort. SARS-CoV-2 anti-spike IgG levels were measured before first SARS-CoV-2 vaccination and at day 21-28, 90 and 180, as well as after booster vaccination. Breakthrough infections were captured through the Danish National Microbiology database. incidence rate ratio (IRR) for breakthrough infection at time-updated anti-spike IgG levels was determined using Poisson regression. Among 6076 participants, 127 and 364 breakthrough infections due to Delta and Omicron variants were observed. IRR was 0.29 (95% CI 0.15-0.56) for breakthrough infection with the Delta variant, comparing the highest and lowest quintiles of anti-spike IgG. For Omicron, no significant differences in IRR were observed. These results suggest that quantitative level of anti-spike IgG have limited impact on the risk of breakthrough infection with Omicron.
AB - SARS-CoV-2 variants of concern have continuously evolved and may erode vaccine induced immunity. In this observational cohort study, we determine the risk of breakthrough infection in a fully vaccinated cohort. SARS-CoV-2 anti-spike IgG levels were measured before first SARS-CoV-2 vaccination and at day 21-28, 90 and 180, as well as after booster vaccination. Breakthrough infections were captured through the Danish National Microbiology database. incidence rate ratio (IRR) for breakthrough infection at time-updated anti-spike IgG levels was determined using Poisson regression. Among 6076 participants, 127 and 364 breakthrough infections due to Delta and Omicron variants were observed. IRR was 0.29 (95% CI 0.15-0.56) for breakthrough infection with the Delta variant, comparing the highest and lowest quintiles of anti-spike IgG. For Omicron, no significant differences in IRR were observed. These results suggest that quantitative level of anti-spike IgG have limited impact on the risk of breakthrough infection with Omicron.
KW - Antibodies, Viral
KW - COVID-19
KW - COVID-19 Vaccines
KW - Humans
KW - Immunoglobulin G
KW - SARS-CoV-2
UR - http://www.scopus.com/inward/record.url?scp=85135226100&partnerID=8YFLogxK
U2 - 10.1038/s41467-022-32254-8
DO - 10.1038/s41467-022-32254-8
M3 - Journal article
C2 - 35915081
SN - 2041-1723
VL - 13
JO - Nature Communications
JF - Nature Communications
IS - 1
M1 - 4466
ER -