TY - JOUR
T1 - Linoleic acid in adipose tissue and the risk of myocardial infarction
T2 - a case-cohort study
AU - Nielsen, Maja H
AU - Frydenberg, Morten
AU - Bork, Christian Sørensen
AU - Venø, Stine Krogh
AU - Tjønneland, Anne
AU - Schmidt, Erik Berg
AU - Overvad, Kim
AU - Jakobsen, Marianne Uhre
N1 - © 2021. Springer-Verlag GmbH, DE part of Springer Nature.
PY - 2021/10
Y1 - 2021/10
N2 - PURPOSE: We investigated risk of myocardial infarction (MI) associated with the content of linoleic acid (LA) in adipose tissue, a biomarker of long-term dietary intake of LA and a marker of endogenous LA exposure.METHODS: Between 1993 and 1997, 57,053 middle-aged subjects were included in the Danish Diet, Cancer and Health cohort. We performed a case-cohort study that included a random sample of the full cohort (n = 3167) and all incident MI cases appearing during 16 years of follow-up (n = 2819). Information on incident MI cases was obtained by linkage with Danish nationwide registries. Adipose tissue biopsies were taken from the buttocks of the participants, and their fatty acid composition was determined using gas chromatography. HRs (hazard ratios) with 95% confidence intervals (CIs) were used to describe the associations between content of LA in adipose tissue and the risk of MI. HRs were calculated using weighted Cox proportional hazards regression with robust variance.RESULTS: After adjustment for established risk factors of MI, adipose tissue content of LA was not associated with the risk of MI in men and women combined (quintiles 5 versus 1, HR, 1.03 (95% CI, 0.85-1.25), P-trend = 0.970) or in men and women separately (quintiles 5 versus 1, HR, 1.05 (95% CI, 0.83-1.33), P-trend = 0.871 and quintiles 5 versus 1, HR, 0.99 (95% CI 0.72-1.37), P-trend = 0.928, respectively). Investigating the association between LA and MI with a shorter, 5- or 10-year duration of follow-up provided similar results.CONCLUSION: Content of LA in adipose tissue was not associated with the risk of MI.
AB - PURPOSE: We investigated risk of myocardial infarction (MI) associated with the content of linoleic acid (LA) in adipose tissue, a biomarker of long-term dietary intake of LA and a marker of endogenous LA exposure.METHODS: Between 1993 and 1997, 57,053 middle-aged subjects were included in the Danish Diet, Cancer and Health cohort. We performed a case-cohort study that included a random sample of the full cohort (n = 3167) and all incident MI cases appearing during 16 years of follow-up (n = 2819). Information on incident MI cases was obtained by linkage with Danish nationwide registries. Adipose tissue biopsies were taken from the buttocks of the participants, and their fatty acid composition was determined using gas chromatography. HRs (hazard ratios) with 95% confidence intervals (CIs) were used to describe the associations between content of LA in adipose tissue and the risk of MI. HRs were calculated using weighted Cox proportional hazards regression with robust variance.RESULTS: After adjustment for established risk factors of MI, adipose tissue content of LA was not associated with the risk of MI in men and women combined (quintiles 5 versus 1, HR, 1.03 (95% CI, 0.85-1.25), P-trend = 0.970) or in men and women separately (quintiles 5 versus 1, HR, 1.05 (95% CI, 0.83-1.33), P-trend = 0.871 and quintiles 5 versus 1, HR, 0.99 (95% CI 0.72-1.37), P-trend = 0.928, respectively). Investigating the association between LA and MI with a shorter, 5- or 10-year duration of follow-up provided similar results.CONCLUSION: Content of LA in adipose tissue was not associated with the risk of MI.
KW - Adipose tissue
KW - Coronary heart disease
KW - Linoleic acid
KW - Myocardial infarction
KW - N-6 fatty acids
KW - Omega-6 fatty acids
UR - http://www.scopus.com/inward/record.url?scp=85102282379&partnerID=8YFLogxK
U2 - 10.1007/s00394-021-02526-y
DO - 10.1007/s00394-021-02526-y
M3 - Journal article
C2 - 33687534
SN - 1436-6207
VL - 60
SP - 3639
EP - 3646
JO - European Journal of Nutrition
JF - European Journal of Nutrition
IS - 7
ER -