Lipid-rich carotid artery plaques appear echolucent on ultrasound B-mode images and may be associated with intraplaque haemorrhage

M L Grønholdt; B M Wiebe; H Laursen; T. G. Nielsen; T V Schroeder; H Sillesen

Lipid-rich carotid artery plaques appear echolucent on ultrasound B-mode images and may be associated with intraplaque haemorrhage

M L Grønholdt, B M Wiebe, H Laursen, T. G. Nielsen, T V Schroeder, H Sillesen

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Abstract

OBJECTIVE: To relate the histological composition of carotid artery plaques with morphology as evaluated by B-mode ultrasound.

DESIGN: Prospective study.

MATERIAL AND METHODS: Seventy-eight symptomatic patients underwent carotid endarterectomy after preoperative ultrasound Duplex scanning evaluating plaque morphology. Morphometric analysis of the removed specimen was performed in order to quantify content of lipid, haemorrhage, calcification and fibrous tissue.

RESULTS: Echolucent plaques contained more lipid (p = 0.01) and less calcification (p = 0.01) and fibrous tissue (p = 0.03) than echo-rich plaques. Intraplaque haemorrhage was directly related to lipid content (p = 0.004) and inversely related to amount of fibrous tissue in the plaque (p = 0.02).

CONCLUSION: The intensity of the reflected B-mode ultrasound signal appears related to the histological composition of the plaque. The association between intraplaque haemorrhage and a high lipid content may support the theory of the lipid-rich plaque being more prone to rupture.

Originalsprog	Engelsk
Tidsskrift	E J V E S Extra
Vol/bind	14
Udgave nummer	6
Sider (fra-til)	439-445
Antal sider	7
ISSN	1078-5884
Status	Udgivet - 1997
Udgivet eksternt	Ja

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Grønholdt, M. L., Wiebe, B. M., Laursen, H., Nielsen, T. G., Schroeder, T. V., & Sillesen, H. (1997). Lipid-rich carotid artery plaques appear echolucent on ultrasound B-mode images and may be associated with intraplaque haemorrhage. E J V E S Extra, 14(6), 439-445. http://ac.els-cdn.com/S1078588497801219/1-s2.0-S1078588497801219-main.pdf?_tid=25d0aa4e-a8ae-11e5-ba63-00000aacb35d&acdnat=1450790341_6e0244b9c7b0cd75d615c49706f5401b

@article{53163ce6a8c24d5080e6d4ae86560d99,

title = "Lipid-rich carotid artery plaques appear echolucent on ultrasound B-mode images and may be associated with intraplaque haemorrhage",

abstract = "OBJECTIVE: To relate the histological composition of carotid artery plaques with morphology as evaluated by B-mode ultrasound.DESIGN: Prospective study.MATERIAL AND METHODS: Seventy-eight symptomatic patients underwent carotid endarterectomy after preoperative ultrasound Duplex scanning evaluating plaque morphology. Morphometric analysis of the removed specimen was performed in order to quantify content of lipid, haemorrhage, calcification and fibrous tissue.RESULTS: Echolucent plaques contained more lipid (p = 0.01) and less calcification (p = 0.01) and fibrous tissue (p = 0.03) than echo-rich plaques. Intraplaque haemorrhage was directly related to lipid content (p = 0.004) and inversely related to amount of fibrous tissue in the plaque (p = 0.02).CONCLUSION: The intensity of the reflected B-mode ultrasound signal appears related to the histological composition of the plaque. The association between intraplaque haemorrhage and a high lipid content may support the theory of the lipid-rich plaque being more prone to rupture.",

keywords = "Arteriosclerosis, Carotid Artery, Internal, Carotid Stenosis, Endarterectomy, Carotid, Female, Hemorrhage, Humans, Lipids, Lipoproteins, Male, Middle Aged, Prospective Studies, Reproducibility of Results, Risk Factors",

author = "Gr{\o}nholdt, {M L} and Wiebe, {B M} and H Laursen and Nielsen, {T. G.} and Schroeder, {T V} and H Sillesen",

year = "1997",

language = "English",

volume = "14",

pages = "439--445",

journal = "E J V E S Extra",

issn = "1078-5884",

publisher = "Pergamon Press",

number = "6",

}

Grønholdt, ML, Wiebe, BM, Laursen, H, Nielsen, TG, Schroeder, TV & Sillesen, H 1997, 'Lipid-rich carotid artery plaques appear echolucent on ultrasound B-mode images and may be associated with intraplaque haemorrhage', E J V E S Extra, bind 14, nr. 6, s. 439-445. <http://ac.els-cdn.com/S1078588497801219/1-s2.0-S1078588497801219-main.pdf?_tid=25d0aa4e-a8ae-11e5-ba63-00000aacb35d&acdnat=1450790341_6e0244b9c7b0cd75d615c49706f5401b>

TY - JOUR

T1 - Lipid-rich carotid artery plaques appear echolucent on ultrasound B-mode images and may be associated with intraplaque haemorrhage

AU - Grønholdt, M L

AU - Wiebe, B M

AU - Laursen, H

AU - Nielsen, T. G.

AU - Schroeder, T V

AU - Sillesen, H

PY - 1997

Y1 - 1997

N2 - OBJECTIVE: To relate the histological composition of carotid artery plaques with morphology as evaluated by B-mode ultrasound.DESIGN: Prospective study.MATERIAL AND METHODS: Seventy-eight symptomatic patients underwent carotid endarterectomy after preoperative ultrasound Duplex scanning evaluating plaque morphology. Morphometric analysis of the removed specimen was performed in order to quantify content of lipid, haemorrhage, calcification and fibrous tissue.RESULTS: Echolucent plaques contained more lipid (p = 0.01) and less calcification (p = 0.01) and fibrous tissue (p = 0.03) than echo-rich plaques. Intraplaque haemorrhage was directly related to lipid content (p = 0.004) and inversely related to amount of fibrous tissue in the plaque (p = 0.02).CONCLUSION: The intensity of the reflected B-mode ultrasound signal appears related to the histological composition of the plaque. The association between intraplaque haemorrhage and a high lipid content may support the theory of the lipid-rich plaque being more prone to rupture.

AB - OBJECTIVE: To relate the histological composition of carotid artery plaques with morphology as evaluated by B-mode ultrasound.DESIGN: Prospective study.MATERIAL AND METHODS: Seventy-eight symptomatic patients underwent carotid endarterectomy after preoperative ultrasound Duplex scanning evaluating plaque morphology. Morphometric analysis of the removed specimen was performed in order to quantify content of lipid, haemorrhage, calcification and fibrous tissue.RESULTS: Echolucent plaques contained more lipid (p = 0.01) and less calcification (p = 0.01) and fibrous tissue (p = 0.03) than echo-rich plaques. Intraplaque haemorrhage was directly related to lipid content (p = 0.004) and inversely related to amount of fibrous tissue in the plaque (p = 0.02).CONCLUSION: The intensity of the reflected B-mode ultrasound signal appears related to the histological composition of the plaque. The association between intraplaque haemorrhage and a high lipid content may support the theory of the lipid-rich plaque being more prone to rupture.

KW - Arteriosclerosis

KW - Carotid Artery, Internal

KW - Carotid Stenosis

KW - Endarterectomy, Carotid

KW - Female

KW - Hemorrhage

KW - Humans

KW - Lipids

KW - Lipoproteins

KW - Male

KW - Middle Aged

KW - Prospective Studies

KW - Reproducibility of Results

KW - Risk Factors

M3 - Journal article

C2 - 9467517

SN - 1078-5884

VL - 14

SP - 439

EP - 445

JO - E J V E S Extra

JF - E J V E S Extra

IS - 6

ER -

Lipid-rich carotid artery plaques appear echolucent on ultrasound B-mode images and may be associated with intraplaque haemorrhage

Abstract

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