Abstract
Loperamide is an over-the-counter anti-diarrhoeal agent. In supratherapeutic doses, loperamide penetrates the blood-brain barrier, exceeds the efflux capacity of P-glycoprotein and binds to central opioid receptors. We report a case of a 33-year-old woman with a history of opioid abuse, who had a long-term excessive daily intake of loperamide in order to achieve a euphoric effect. Cardiac arrhythmias, respiratory depression and death have been reported in relation to excessive loperamide use.
Bidragets oversatte titel | A young woman's loperamide abuse for the achievement of euphoric effect |
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Originalsprog | Dansk |
Artikelnummer | V11190650 |
Tidsskrift | Ugeskrift for Laeger |
Vol/bind | 182 |
Udgave nummer | 21 |
Sider (fra-til) | 2052-2053 |
ISSN | 0041-5782 |
Status | Udgivet - 16 mar. 2020 |