Low serum level of vitamin d at time of diagnosis is associated with higher one-year remission rate in patients with newly diagnosed ra, treated aggressively during follow-up: post-hoc analyses of the cimestra trial

Mette Herly, Kristian Stengaard-Pedersen, Peter Vestergaard, Robin Christensen, Mikkel Östergaard, Peter Junker, Merete L. Hetland, Kim Hørslev-Petersen, Torkell Ellingsen

Publikation: Bidrag til tidsskriftKonferenceabstrakt i tidsskriftForskningpeer review

Resumé

Background Vitamin D is often low in Rheumatoid Arthritis(RA), and immunomodulatory properties of vitamin D might be associated with disease-course in RA.(1)Objectives To evaluate association between baseline vitamin D metabolites and one-year remission, in newly diagnosed, treatment-naive RA patients, aggressively treated during follow-up.Methods The CIMESTRA-cohort comprises 160 newly diagnosed RA patients, treated aiming at remission with methotrexate and intraarticular steroid, further randomized 1:1 to ciclosporine or placebo-ciclosporine.(2) A total of 158 patients had vitamin D metabolites measured at time of diagnosis. Dietary vitamin D supplementation was recommended in accordance with the national guidelines. Serum vitamin Dtotal (sum of 25OHD2 and 25OHD3) and 1,25(OH)2D at time of diagnoses were measured by LC-MS/MS or RIA. Dtotal were dichotomized at 50 nmol/l, and 1,25(OH)2D categorized in tertiles. Primary outcome was remission (DAS28-CRP
OriginalsprogEngelsk
ArtikelnummerSAT0092
TidsskriftAnnals of the Rheumatic Diseases
Vol/bind78
Udgave nummerSuppl. 2
Sider (fra-til)1112-1112
Antal sider1
ISSN0003-4967
DOI
StatusUdgivet - 2019
BegivenhedAnnual European Congress of Rheumatology, EULAR 2019 - Madrid, Spanien
Varighed: 12 jun. 201915 jun. 2019
https://www.congress.eular.org/

Konference

KonferenceAnnual European Congress of Rheumatology, EULAR 2019
LandSpanien
ByMadrid
Periode12/06/201915/06/2019
Internetadresse

Citer dette

Herly, Mette ; Stengaard-Pedersen, Kristian ; Vestergaard, Peter ; Christensen, Robin ; Östergaard, Mikkel ; Junker, Peter ; Hetland, Merete L. ; Hørslev-Petersen, Kim ; Ellingsen, Torkell. / Low serum level of vitamin d at time of diagnosis is associated with higher one-year remission rate in patients with newly diagnosed ra, treated aggressively during follow-up : post-hoc analyses of the cimestra trial. I: Annals of the Rheumatic Diseases. 2019 ; Bind 78, Nr. Suppl. 2. s. 1112-1112.
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abstract = "Background Vitamin D is often low in Rheumatoid Arthritis(RA), and immunomodulatory properties of vitamin D might be associated with disease-course in RA.(1)Objectives To evaluate association between baseline vitamin D metabolites and one-year remission, in newly diagnosed, treatment-naive RA patients, aggressively treated during follow-up.Methods The CIMESTRA-cohort comprises 160 newly diagnosed RA patients, treated aiming at remission with methotrexate and intraarticular steroid, further randomized 1:1 to ciclosporine or placebo-ciclosporine.(2) A total of 158 patients had vitamin D metabolites measured at time of diagnosis. Dietary vitamin D supplementation was recommended in accordance with the national guidelines. Serum vitamin Dtotal (sum of 25OHD2 and 25OHD3) and 1,25(OH)2D at time of diagnoses were measured by LC-MS/MS or RIA. Dtotal were dichotomized at 50 nmol/l, and 1,25(OH)2D categorized in tertiles. Primary outcome was remission (DAS28-CRP",
author = "Mette Herly and Kristian Stengaard-Pedersen and Peter Vestergaard and Robin Christensen and Mikkel {\"O}stergaard and Peter Junker and Hetland, {Merete L.} and Kim H{\o}rslev-Petersen and Torkell Ellingsen",
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Low serum level of vitamin d at time of diagnosis is associated with higher one-year remission rate in patients with newly diagnosed ra, treated aggressively during follow-up : post-hoc analyses of the cimestra trial. / Herly, Mette; Stengaard-Pedersen, Kristian; Vestergaard, Peter; Christensen, Robin; Östergaard, Mikkel; Junker, Peter; Hetland, Merete L.; Hørslev-Petersen, Kim; Ellingsen, Torkell.

I: Annals of the Rheumatic Diseases, Bind 78, Nr. Suppl. 2, SAT0092, 2019, s. 1112-1112.

Publikation: Bidrag til tidsskriftKonferenceabstrakt i tidsskriftForskningpeer review

TY - ABST

T1 - Low serum level of vitamin d at time of diagnosis is associated with higher one-year remission rate in patients with newly diagnosed ra, treated aggressively during follow-up

T2 - post-hoc analyses of the cimestra trial

AU - Herly, Mette

AU - Stengaard-Pedersen, Kristian

AU - Vestergaard, Peter

AU - Christensen, Robin

AU - Östergaard, Mikkel

AU - Junker, Peter

AU - Hetland, Merete L.

AU - Hørslev-Petersen, Kim

AU - Ellingsen, Torkell

PY - 2019

Y1 - 2019

N2 - Background Vitamin D is often low in Rheumatoid Arthritis(RA), and immunomodulatory properties of vitamin D might be associated with disease-course in RA.(1)Objectives To evaluate association between baseline vitamin D metabolites and one-year remission, in newly diagnosed, treatment-naive RA patients, aggressively treated during follow-up.Methods The CIMESTRA-cohort comprises 160 newly diagnosed RA patients, treated aiming at remission with methotrexate and intraarticular steroid, further randomized 1:1 to ciclosporine or placebo-ciclosporine.(2) A total of 158 patients had vitamin D metabolites measured at time of diagnosis. Dietary vitamin D supplementation was recommended in accordance with the national guidelines. Serum vitamin Dtotal (sum of 25OHD2 and 25OHD3) and 1,25(OH)2D at time of diagnoses were measured by LC-MS/MS or RIA. Dtotal were dichotomized at 50 nmol/l, and 1,25(OH)2D categorized in tertiles. Primary outcome was remission (DAS28-CRP

AB - Background Vitamin D is often low in Rheumatoid Arthritis(RA), and immunomodulatory properties of vitamin D might be associated with disease-course in RA.(1)Objectives To evaluate association between baseline vitamin D metabolites and one-year remission, in newly diagnosed, treatment-naive RA patients, aggressively treated during follow-up.Methods The CIMESTRA-cohort comprises 160 newly diagnosed RA patients, treated aiming at remission with methotrexate and intraarticular steroid, further randomized 1:1 to ciclosporine or placebo-ciclosporine.(2) A total of 158 patients had vitamin D metabolites measured at time of diagnosis. Dietary vitamin D supplementation was recommended in accordance with the national guidelines. Serum vitamin Dtotal (sum of 25OHD2 and 25OHD3) and 1,25(OH)2D at time of diagnoses were measured by LC-MS/MS or RIA. Dtotal were dichotomized at 50 nmol/l, and 1,25(OH)2D categorized in tertiles. Primary outcome was remission (DAS28-CRP

U2 - 10.1136/annrheumdis-2019-eular.1569

DO - 10.1136/annrheumdis-2019-eular.1569

M3 - Conference abstract in journal

VL - 78

SP - 1112

EP - 1112

JO - Annals of the Rheumatic Diseases

JF - Annals of the Rheumatic Diseases

SN - 0003-4967

IS - Suppl. 2

M1 - SAT0092

ER -