Abstract
Background Vitamin D is often low in Rheumatoid Arthritis(RA), and immunomodulatory properties of vitamin D might be associated with disease-course in RA.(1)Objectives To evaluate association between baseline vitamin D metabolites and one-year remission, in newly diagnosed, treatment-naive RA patients, aggressively treated during follow-up.Methods The CIMESTRA-cohort comprises 160 newly diagnosed RA patients, treated aiming at remission with methotrexate and intraarticular steroid, further randomized 1:1 to ciclosporine or placebo-ciclosporine.(2) A total of 158 patients had vitamin D metabolites measured at time of diagnosis. Dietary vitamin D supplementation was recommended in accordance with the national guidelines. Serum vitamin Dtotal (sum of 25OHD2 and 25OHD3) and 1,25(OH)2D at time of diagnoses were measured by LC-MS/MS or RIA. Dtotal were dichotomized at 50 nmol/l, and 1,25(OH)2D categorized in tertiles. Primary outcome was remission (DAS28-CRP
Originalsprog | Engelsk |
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Artikelnummer | SAT0092 |
Tidsskrift | Annals of the Rheumatic Diseases |
Vol/bind | 78 |
Udgave nummer | Suppl. 2 |
Sider (fra-til) | 1112-1112 |
Antal sider | 1 |
ISSN | 0003-4967 |
DOI | |
Status | Udgivet - 2019 |
Begivenhed | Annual European Congress of Rheumatology, EULAR 2019 - Madrid, Spanien Varighed: 12 jun. 2019 → 15 jun. 2019 https://www.congress.eular.org/ |
Konference
Konference | Annual European Congress of Rheumatology, EULAR 2019 |
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Land/Område | Spanien |
By | Madrid |
Periode | 12/06/2019 → 15/06/2019 |
Internetadresse |