Abstract
In a study of lymphocyte subpopulations in peripheral blood during infectious mononucleosis the lymphocytosis was found to be of T-cell origin (i.e. E-RFC), while the number of non T lymphocytes (i.e. EA-, EAC-RFC and SmIg + ve cells) was normal in 7 out of 8 patients. Ten patients were tested for the presence of HLA-DR determinants on their B and T cells and not only B lymphocytes but also a great part (31--75%) of T cells were lysed by the anti HLA-DR testsera, indicating that HLA-DR determinants are expressed on a population of T cells in IM patients. After recovery all patients were retested and showed a normal pattern of HLA-DR typing. This indicates an increase of HLA-DR antigens on T cells or a vigorous proliferation of a small DR-positive T-cell subpopulation during the acute stage of IM.
Originalsprog | Engelsk |
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Tidsskrift | Acta pathologica et microbiologica Scandinavica. Section C, Immunology |
Vol/bind | 86C |
Udgave nummer | 6 |
Sider (fra-til) | 307-14 |
Antal sider | 8 |
ISSN | 0304-1328 |
Status | Udgivet - dec. 1978 |
Udgivet eksternt | Ja |