TY - JOUR
T1 - Macrophage Long Non-Coding RNAs in Pathogenesis of Cardiovascular Disease
AU - Wysoczynski, Marcin
AU - Kim, Jae
AU - Moore, Joseph B
AU - Uchida, Shizuka
PY - 2020/7/11
Y1 - 2020/7/11
N2 - Chronic inflammation is inextricably linked to cardiovascular disease (CVD). Macrophages themselves play important roles in atherosclerosis, as well as acute and chronic heart failure. Although the role of macrophages in CVD pathophysiology is well-recognized, little is known regarding the precise mechanisms influencing their function in these contexts. Long non-coding RNAs (lncRNAs) have emerged as significant regulators of macrophage function; as such, there is rising interest in understanding how these nucleic acids influence macrophage signaling, cell fate decisions, and activity in health and disease. In this review, we summarize current knowledge regarding lncRNAs in directing various aspects of macrophage function in CVD. These include foam cell formation, Toll-like receptor (TLR) and NF-kβ signaling, and macrophage phenotype switching. This review will provide a comprehensive understanding concerning previous, ongoing, and future studies of lncRNAs in macrophage functions and their importance in CVD.
AB - Chronic inflammation is inextricably linked to cardiovascular disease (CVD). Macrophages themselves play important roles in atherosclerosis, as well as acute and chronic heart failure. Although the role of macrophages in CVD pathophysiology is well-recognized, little is known regarding the precise mechanisms influencing their function in these contexts. Long non-coding RNAs (lncRNAs) have emerged as significant regulators of macrophage function; as such, there is rising interest in understanding how these nucleic acids influence macrophage signaling, cell fate decisions, and activity in health and disease. In this review, we summarize current knowledge regarding lncRNAs in directing various aspects of macrophage function in CVD. These include foam cell formation, Toll-like receptor (TLR) and NF-kβ signaling, and macrophage phenotype switching. This review will provide a comprehensive understanding concerning previous, ongoing, and future studies of lncRNAs in macrophage functions and their importance in CVD.
KW - Cardiovascular disease
KW - Inflammation
KW - LncRNA
KW - Macrophage
UR - http://www.scopus.com/inward/record.url?scp=85094816455&partnerID=8YFLogxK
U2 - 10.3390/ncrna6030028
DO - 10.3390/ncrna6030028
M3 - Review article
C2 - 32664594
SN - 2311-553X
VL - 6
SP - 1
EP - 18
JO - Non-coding RNA
JF - Non-coding RNA
IS - 3
M1 - 28
ER -