TY - JOUR
T1 - Management and prognosis of atrial fibrillation in diabetic patients
T2 - an EORP-AF General Pilot Registry report
AU - Fumagalli, Stefano
AU - Said, Salah A
AU - Laroche, Cecile
AU - Gabbai, Debbie
AU - Boni, Serena
AU - Marchionni, Niccolò
AU - Boriani, Giuseppe
AU - Maggioni, Aldo P
AU - Musialik-Lydka, Agata
AU - Sokal, Adam
AU - Petersen, Jens
AU - Crijns, Harry J G M
AU - Lip, Gregory Y H
AU - EORP-AF General Pilot Registry Investigators
A2 - Hellum, Camilla Fragtrup
A2 - Mortensen, Bettina
A2 - Sørensen, Bodil Ginnerup
A2 - Joensen, Albert Marni
A2 - Rasmussen, Lars Hvilsted
PY - 2018/7
Y1 - 2018/7
N2 - Aims: Diabetes mellitus (DM) is one of the most important cardiovascular (CV) risk factors. The aim of this study was to evaluate clinical correlates of DM, including management and outcomes, in the EURObservational Research Programme (EORP) - Atrial Fibrillation (AF) General Pilot (EORP-AF) Registry of the European Society of Cardiology.Methods and Results: We studied consecutive patients (N = 3101) enrolled in 70 centers of 9 European countries between February 2012 and March 2013, and compared diabetics with non-diabetics during a one-year follow-up. In the overall cohort, the prevalence of DM was 20.6%. Diabetics were older (71±9 vs. 68±12 years, p < 0.0001) and had more comorbidities, higher CHA2DS2-VASc score (4.6±1.6 vs. 2.9±1.7, p < 0.0001) and higher prevalence of permanent AF (21.5 vs. 16.0%, p = 0.0022). Quality of life amongst DM patients was significantly worse (AF-QoL score: 45.2±19.2 vs. 49.3±20.1, p < 0.0001). Amongst diabetics, the use of electrical cardioversion (16.2 vs. 24.6%, p < 0.0001) and catheter ablation (3.3 vs. 8.6%, p < 0.0001) was lower, whilst oral anticoagulants were more often prescribed (84.3 vs. 78.9%, p = 0.0027). After one year, diabetic patients had significantly higher all-cause (11.9 vs. 4.9%, p < 0.0001), CV (6.2 vs. 1.9%, p < 0.0001) and non-CV mortality (2.3 vs. 1.1%, p = 0.0356).Conclusion: In AF patients, DM is associated with a higher prevalence of comorbidities and a worse quality of life. After one year, all-cause, CV and non-CV mortality were significantly higher in diabetic subjects.
AB - Aims: Diabetes mellitus (DM) is one of the most important cardiovascular (CV) risk factors. The aim of this study was to evaluate clinical correlates of DM, including management and outcomes, in the EURObservational Research Programme (EORP) - Atrial Fibrillation (AF) General Pilot (EORP-AF) Registry of the European Society of Cardiology.Methods and Results: We studied consecutive patients (N = 3101) enrolled in 70 centers of 9 European countries between February 2012 and March 2013, and compared diabetics with non-diabetics during a one-year follow-up. In the overall cohort, the prevalence of DM was 20.6%. Diabetics were older (71±9 vs. 68±12 years, p < 0.0001) and had more comorbidities, higher CHA2DS2-VASc score (4.6±1.6 vs. 2.9±1.7, p < 0.0001) and higher prevalence of permanent AF (21.5 vs. 16.0%, p = 0.0022). Quality of life amongst DM patients was significantly worse (AF-QoL score: 45.2±19.2 vs. 49.3±20.1, p < 0.0001). Amongst diabetics, the use of electrical cardioversion (16.2 vs. 24.6%, p < 0.0001) and catheter ablation (3.3 vs. 8.6%, p < 0.0001) was lower, whilst oral anticoagulants were more often prescribed (84.3 vs. 78.9%, p = 0.0027). After one year, diabetic patients had significantly higher all-cause (11.9 vs. 4.9%, p < 0.0001), CV (6.2 vs. 1.9%, p < 0.0001) and non-CV mortality (2.3 vs. 1.1%, p = 0.0356).Conclusion: In AF patients, DM is associated with a higher prevalence of comorbidities and a worse quality of life. After one year, all-cause, CV and non-CV mortality were significantly higher in diabetic subjects.
KW - Journal Article
U2 - 10.1093/ehjcvp/pvx037
DO - 10.1093/ehjcvp/pvx037
M3 - Journal article
C2 - 29309557
SN - 2055-6837
VL - 4
SP - 172
EP - 179
JO - European Heart Journal - Cardiovascular Pharmacotherapy
JF - European Heart Journal - Cardiovascular Pharmacotherapy
IS - 3
ER -