Abstract
UNLABELLED: Marine n-3 polyunsaturated fatty acids (PUFAs) may improve cardiovascular, renal, and mental health. No previous trial has investigated the effects of marine n-3 PUFA supplementation on quality of life (QoL) indices after renal transplant.
METHODS: In this trial, 132 renal transplant recipients were randomized to receive daily either 2.6 g of marine n-3 PUFAs or an equivalent dose of olive oil (controls) on top of standard care for 44 weeks. We used a Short Form 36 (SF-36) questionnaire at baseline (8 weeks post transplant) and at the end of the study (1 year after transplant) to assess QoL. Results were expressed as net change (Δ) in SF-36 individual and composite mental and physical scores during follow-up.
RESULTS: We found no improvement of Δ SF-36 individual or composite scores after marine n-3 PUFA supplementation compared with controls. In per-protocol analysis, patients who received marine n-3 PUFAs had a Δ emotional role function (mean, 17% [SD, 50%] vs mean, 3% [SD, 37%]; P = .11). In addition, plasma marine n-3 PUFA levels showed a weak but statistically significant correlation with Δ composite mental function score (r = .18; P = .04).
CONCLUSION: Marine n-3 PUFA supplementation did not improve QoL after renal transplant.
| Originalsprog | Engelsk |
|---|---|
| Tidsskrift | Transplantation Proceedings |
| Vol/bind | 51 |
| Udgave nummer | 2 |
| Sider (fra-til) | 466-469 |
| Antal sider | 4 |
| ISSN | 0041-1345 |
| DOI | |
| Status | Udgivet - mar. 2019 |
| Udgivet eksternt | Ja |
| Begivenhed | 29th Congress of the Scandinavian Transplantation Society - , Estland Varighed: 2 maj 2018 → 4 maj 2018 http://10.1016/j.transproceed.2019.01.082 |
Konference
| Konference | 29th Congress of the Scandinavian Transplantation Society |
|---|---|
| Land/Område | Estland |
| Periode | 02/05/2018 → 04/05/2018 |
| Internetadresse |