Maternal weight determines the association between Hbalc in second half of pregnancy and risk of large for gestational age babies

Gunnar Lauge Nielsen, Claus Dethlefsen, Margrethe Møller, Henrik Toft Sørensen

Publikation: Konferencebidrag uden forlag/tidsskriftPosterForskning

Abstract

Aim: To assess the association between maternal glycosylated haemoglobin (HbA1c) in diabetic pregnancies and the risk of delivering large for gestational age babies (LGA) taking into account maternal body mass index (BMI), weight gain, age, White class, and smoking habits.  Method: We identified all pregnant diabetic women in a Danish county. HbA1c values after 20th gestational week were collected and offspring was categorized as large, normal or small for gestational age. Logistic regression models we fitted to assess the association between HbA1c and risk of delivering a LGA baby taking into account the impact of potential confounding from the above mentioned factors.   Results: We found 209 singleton pregnancies of which 59% (95% CI: 52%-65%) terminated with a LGA baby. HbA1c, BMI, and weight gain were all associated with increasing risk of delivering a LGA baby. Analyses stratified on maternal BMI disclosed that the association was restricted to pregnancies with a pre-pregnancy BMI >23 kg/m2 below that we found no association.  Conclusion: The association between glycosylated haemoglobin and birth of a LGA baby seems to be restricted to women with BMI >23 kg/m2.
OriginalsprogEngelsk
Publikationsdato2007
Antal sider1
StatusUdgivet - 2007
BegivenhedInternational Symposium on Diabetes and Pregnancy - Instanbul, Tyrkiet
Varighed: 29 mar. 200731 mar. 2007
Konferencens nummer: 4

Konference

KonferenceInternational Symposium on Diabetes and Pregnancy
Nummer4
Land/OmrådeTyrkiet
ByInstanbul
Periode29/03/200731/03/2007

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