MicroRNA-22 Is a Key Regulator of Lipid and Metabolic Homeostasis

Riccardo Panella, Andreas Petri, Bhavna N. Desai, Sharmila Fagoonee, Cody A. Cotton, Piercen K. Nguyen, Eric M. Lundin, Alexandre Wagshal, Da-Zhi Wang, Anders M. Näär, Ioannis S. Vlachos, Eleftheria Maratos-Flier, Fiorella Altruda, Sakari Kauppinen*, Pier Paolo Pandolfi*


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1 Citationer (Scopus)
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Obesity is a growing public health problem associated with increased risk of type 2 diabetes, cardiovascular disease, nonalcoholic fatty liver disease (NAFLD) and cancer. Here, we identify microRNA-22 (miR-22) as an essential rheostat involved in the control of lipid and energy homeostasis as well as the onset and maintenance of obesity. We demonstrate through knockout and transgenic mouse models that miR-22 loss-of-function protects against obesity and hepatic steatosis, while its overexpression promotes both phenotypes even when mice are fed a regular chow diet. Mechanistically, we show that miR-22 controls multiple pathways related to lipid biogenesis and differentiation. Importantly, genetic ablation of miR-22 favors metabolic rewiring towards higher energy expenditure and browning of white adipose tissue, suggesting that modulation of miR-22 could represent a viable therapeutic strategy for treatment of obesity and other metabolic disorders.

TidsskriftInternational Journal of Molecular Sciences
Udgave nummer16
StatusUdgivet - 17 aug. 2023


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