Modelling of serial carcinoembryonic antigen changes in colorectal cancer

J Carl, S M Bentzen, B Nørgaard-Pedersen, O Kronborg

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Abstract

Carcinoembryonic antigen (CEA) is a tumour marker mainly used for detection of recurrent colorectal cancer. CEA series in 295 patients, who had a macroscopic radical resection of a primary colorectal cancer were studied. A kinetic model was fitted to CEA series of individual patients. Applying the kinetic model recurrences were identified with a sensitivity of 70-80% and specificity of 80-90%. Simulations were performed in order to find the optimal sampling strategy for CEA during follow-up. Simulations showed that CEA determinations at a few weeks interval between would be optimal for early detection of recurrences.

OriginalsprogEngelsk
TidsskriftScandinavian Journal of Clinical & Laboratory Investigation
Vol/bind53
Udgave nummer7
Sider (fra-til)751-5
Antal sider5
ISSN0036-5513
StatusUdgivet - nov. 1993
Udgivet eksterntJa

Emneord

  • Carcinoembryonic Antigen
  • Colorectal Neoplasms
  • Humans
  • Models, Biological
  • Models, Statistical
  • Neoplasm Recurrence, Local

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