Abstract
Carcinoembryonic antigen (CEA) is a tumour marker mainly used for detection of recurrent colorectal cancer. CEA series in 295 patients, who had a macroscopic radical resection of a primary colorectal cancer were studied. A kinetic model was fitted to CEA series of individual patients. Applying the kinetic model recurrences were identified with a sensitivity of 70-80% and specificity of 80-90%. Simulations were performed in order to find the optimal sampling strategy for CEA during follow-up. Simulations showed that CEA determinations at a few weeks interval between would be optimal for early detection of recurrences.
Originalsprog | Engelsk |
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Tidsskrift | Scandinavian Journal of Clinical & Laboratory Investigation |
Vol/bind | 53 |
Udgave nummer | 7 |
Sider (fra-til) | 751-5 |
Antal sider | 5 |
ISSN | 0036-5513 |
Status | Udgivet - nov. 1993 |
Udgivet eksternt | Ja |
Emneord
- Carcinoembryonic Antigen
- Colorectal Neoplasms
- Humans
- Models, Biological
- Models, Statistical
- Neoplasm Recurrence, Local