Abstract
The Norwegian Lundehund breed of dog has undergone a severe loss of genetic diversity as a result of inbreeding and epizootics of canine distemper. As a consequence, the breed is extremely homogeneous and accurate sex identification is not always possible by standard screening of X-chromosomal loci. To improve our genetic understanding of the breed we genotyped 17 individuals using a genome-wide array of 170 000 single nucleotide polymorphisms (SNPs). Standard analyses based on expected homozygosity of X-chromosomal loci failed in assigning individuals to the correct sex, as determined initially by physical examination and confirmed with the Y-chromosomal marker, amelogenin. This demonstrates that identification of sex using standard SNP assays can be erroneous in highly inbred individuals.
Originalsprog | Engelsk |
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Tidsskrift | Journal of Heredity |
Vol/bind | 106 |
Udgave nummer | 4 |
Sider (fra-til) | 403-406 |
Antal sider | 4 |
ISSN | 0022-1503 |
DOI | |
Status | Udgivet - 20 maj 2015 |
Fingeraftryk
Dyk ned i forskningsemnerne om 'Molecular genetics of sex identification, breed ancestry and polydactyly in the norwegian lundehund breed'. Sammen danner de et unikt fingeraftryk.Forskningsdatasæt
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Data from: Molecular genetics of sex identification, breed ancestry and polydactyly in the Norwegian Lundehund breed
Kropatsch, R. (Ophavsperson), Melis, C. (Ophavsperson), Strønen, A. V. (Ophavsperson), Jensen, H. (Ophavsperson) & Epplen, J. T. (Ophavsperson), Dryad, 27 apr. 2015
DOI: 10.5061/dryad.67sj1, http://datadryad.org/stash/dataset/doi:10.5061/dryad.67sj1 og et link mere, https://zenodo.org/record/4935449 (vis færre)
Datasæt