Music Therapy vs. Music Listening for Negative Symptoms in Schizophrenia: Randomized, Controlled, Assessor- and Patient-Blinded Trial

Inge Nygaard Pedersen; Lars Ole Bonde; Niels Hannibal; Jimmi Nielsen; Jørgen Aagaard; Christian Gold; Lars Rye Bertelsen; Silvia Beatriz Jensen; René Ernst Nielsen

doi:10.3389/fpsyt.2021.738810

Music Therapy vs. Music Listening for Negative Symptoms in Schizophrenia: Randomized, Controlled, Assessor- and Patient-Blinded Trial

Bidragets oversatte titel: Musikterapi overfor musiklytning til reduktion af negative symptomer for mennesker med skizofreni: En randomiseret, kontrolleret, rater- og deltagerblindet effektundersøgelse.

Inge Nygaard Pedersen^*, Lars Ole Bonde, Niels Hannibal, Jimmi Nielsen, Jørgen Aagaard, Christian Gold, Lars Rye Bertelsen, Silvia Beatriz Jensen, René Ernst Nielsen

^*Kontaktforfatter

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

5 Citationer (Scopus)

45 Downloads (Pure)

Abstract

Objective: To investigate the efficacy of music therapy for negative symptoms in patients with schizophrenia.

Methods: Randomized, participant- and assessor-blinded, multicenter, controlled trial including patients diagnosed with schizophrenia according to ICD-10 with predominantly negative symptoms, between 18 and 65 years. Participants were randomized to 25 successive weekly individual sessions (excluding holidays, including cancellation by the participant) of either music therapy conducted by trained music therapists, or music listening together with a social care worker. The primary outcome was reduction in negative symptoms as measured by The Positive and negative Syndrome Scale (PANSS) negative subscale total score, assessed by a blinded rater, utilizing mixed-effects model analysis.

Results: In total, 57 participants were randomized; 39 completed the study's initial 15 weeks, and 30 completed follow-up at 25 weeks. On the primary outcome of PANSS negative subscale, no significant difference was observed between groups with a coefficient of −0.24 (95% CI −1.76 to 1.27, P = 0.754) in the intention to treat analysis, and −0.98 (95% CI −5.06 to 3.09, P = 0.625) when only analyzing completers. Both interventions showed significant reduction from baseline to 25 weeks on PANSS negative subscale. On secondary outcomes, no between group differences were observed in The Brief Negative Symptom Scale, WHOQOL-Bref (Quality of Life), The Helping Alliance Questionnaire and The Global Assessment of Functioning in the intention to treat or completers populations utilizing Mixed Effects Models.

Conclusion: No difference between groups randomized to music therapy vs. musical listening was observed resulting in no clear recommendation for which intervention to use as the first choice for treatment of patients diagnosed with schizophrenia and predominantly having negative symptoms.

Clinical Trial Registration: www.ClinicalTrials.gov, identifier: NCT02942459.

Bidragets oversatte titel	Musikterapi overfor musiklytning til reduktion af negative symptomer for mennesker med skizofreni: En randomiseret, kontrolleret, rater- og deltagerblindet effektundersøgelse.
Originalsprog	Engelsk
Artikelnummer	738810
Tidsskrift	Frontiers in Psychiatry
Vol/bind	12
Antal sider	11
ISSN	1664-0640
DOI	https://doi.org/10.3389/fpsyt.2021.738810
Status	Udgivet - 21 dec. 2021

Bibliografisk note

Emneord

Music Therapy, Music listening, schizophrenia, negative symptoms, blinded trial

FN’s Verdensmål

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10.3389/fpsyt.2021.738810Licens: CC BY 4.0

Music Therapy vs. Music Listening for Negative Symptoms in SchizophreniaForlagets udgivne version, 1,18 MBLicens: CC BY 4.0

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1 Afsluttet

Musikterapi til skizofrenipatienters negative symptomer
Pedersen, I. N., Aagaard, J., Bonde, L. O., Hannibal, N. & Lindvang, C.
01/10/2016 → 01/07/2020
Projekter: Projekt › Forskning

2 Konferenceoplæg

Challenges in music therapy practice and research in schizophrenia, negative symptoms
Inge Nygaard Pedersen (Foredragsholder)
26 jul. 2023
Aktivitet: Foredrag og mundtlige bidrag › Konferenceoplæg
Challenges in music therapy practice and research in schizophrenia, negative symptoms
Inge Nygaard Pedersen (Foredragsholder)
15 jun. 2023
Aktivitet: Foredrag og mundtlige bidrag › Konferenceoplæg

Music Therapy Conversations.
Inge Nygaard Pedersen
18/01/2023
1 element af Mediedækning
Presse/medie
Musikterapi og musiklytning kan reducere skizofrenisymptomer
Inge Nygaard Pedersen
29/04/2022 → 03/05/2022
2 elementer af Mediedækning
Presse/medie

5 Citationer
1 Konferenceabstrakt til konference

Challenges in music therapy practice and research in schizophrenia, negative symptoms: Experiences from the research project: Music Therapy vs. Music listening for Negative Symptoms in Schizophrenia; Randomized, Controlled, Assessor- and Client-Blinded trial.
Bidragets oversatte titel: Udfordringer i musikterapi praksis og forskning inden for skizofreni, negative symptomer: Erfaringer fra forskningsprojektet: Musikterapi vs Musiklytning mod negative symptomer i skizofreni; Et randomiseret, controlleret, screener- og deltagerblindet forsøg..Pedersen, I. N., jun. 2023. 2 s.
Publikation: Konferencebidrag uden forlag/tidsskrift › Konferenceabstrakt til konference › Forskning › peer review

Citationsformater

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abstract = "Objective: To investigate the efficacy of music therapy for negative symptoms in patients with schizophrenia.Methods: Randomized, participant- and assessor-blinded, multicenter, controlled trial including patients diagnosed with schizophrenia according to ICD-10 with predominantly negative symptoms, between 18 and 65 years. Participants were randomized to 25 successive weekly individual sessions (excluding holidays, including cancellation by the participant) of either music therapy conducted by trained music therapists, or music listening together with a social care worker. The primary outcome was reduction in negative symptoms as measured by The Positive and negative Syndrome Scale (PANSS) negative subscale total score, assessed by a blinded rater, utilizing mixed-effects model analysis.Results: In total, 57 participants were randomized; 39 completed the study's initial 15 weeks, and 30 completed follow-up at 25 weeks. On the primary outcome of PANSS negative subscale, no significant difference was observed between groups with a coefficient of −0.24 (95% CI −1.76 to 1.27, P = 0.754) in the intention to treat analysis, and −0.98 (95% CI −5.06 to 3.09, P = 0.625) when only analyzing completers. Both interventions showed significant reduction from baseline to 25 weeks on PANSS negative subscale. On secondary outcomes, no between group differences were observed in The Brief Negative Symptom Scale, WHOQOL-Bref (Quality of Life), The Helping Alliance Questionnaire and The Global Assessment of Functioning in the intention to treat or completers populations utilizing Mixed Effects Models.Conclusion: No difference between groups randomized to music therapy vs. musical listening was observed resulting in no clear recommendation for which intervention to use as the first choice for treatment of patients diagnosed with schizophrenia and predominantly having negative symptoms.",

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note = "Copyright {\textcopyright} 2021 Pedersen, Bonde, Hannibal, Nielsen, Aagaard, Gold, Rye Bertelsen, Jensen and Nielsen.",

year = "2021",

month = dec,

day = "21",

doi = "10.3389/fpsyt.2021.738810",

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T2 - Randomized, Controlled, Assessor- and Patient-Blinded Trial

AU - Pedersen, Inge Nygaard

AU - Bonde, Lars Ole

AU - Hannibal, Niels

AU - Nielsen, Jimmi

AU - Aagaard, Jørgen

AU - Gold, Christian

AU - Bertelsen, Lars Rye

AU - Jensen, Silvia Beatriz

AU - Nielsen, René Ernst

PY - 2021/12/21

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ER -

Music Therapy vs. Music Listening for Negative Symptoms in Schizophrenia: Randomized, Controlled, Assessor- and Patient-Blinded Trial

Abstract

Bibliografisk note

Emneord

FN’s Verdensmål

Adgang til dokumentet

AUB Link

Andre filer og links

Fingeraftryk

Projekter

Musikterapi til skizofrenipatienters negative symptomer

Aktiviteter

Challenges in music therapy practice and research in schizophrenia, negative symptoms

Challenges in music therapy practice and research in schizophrenia, negative symptoms

Presse/Medier

Music Therapy Conversations.

Musikterapi og musiklytning kan reducere skizofrenisymptomer

Publikation

Challenges in music therapy practice and research in schizophrenia, negative symptoms: Experiences from the research project: Music Therapy vs. Music listening for Negative Symptoms in Schizophrenia; Randomized, Controlled, Assessor- and Client-Blinded trial.

Citationsformater