Abstract
Myelodysplastic syndrome and acute myeloid leukaemia are neoplastic diseases caused by genetic alterations of the haematopoietic stem cells. Advances in sequencing techniques have led to a profound understanding of the underlying pathogeneses. Somatic mutations and chromosomal aberrations can be found in > 90% of the cases. The improved understanding of the pathogeneses has translated into better risk stratification and drug development. Somatic mutations may affect targetable protein-kinases or neomorphic enzymes, and new treatment options for specific molecular subgroups of patients are in the pipeline.
Bidragets oversatte titel | Myelodysplastic syndrome and acut leukaemia |
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Originalsprog | Dansk |
Artikelnummer | V03210202 |
Tidsskrift | Ugeskrift for laeger |
Vol/bind | 183 |
Udgave nummer | 20A |
Sider (fra-til) | 1952-1957 |
Antal sider | 6 |
ISSN | 0041-5782 |
Status | Udgivet - 18 okt. 2021 |