Myelodysplastisk syndrom og akutte leukæmier

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Abstract

Myelodysplastic syndrome and acute myeloid leukaemia are neoplastic diseases caused by genetic alterations of the haematopoietic stem cells. Advances in sequencing techniques have led to a profound understanding of the underlying pathogeneses. Somatic mutations and chromosomal aberrations can be found in > 90% of the cases. The improved understanding of the pathogeneses has translated into better risk stratification and drug development. Somatic mutations may affect targetable protein-kinases or neomorphic enzymes, and new treatment options for specific molecular subgroups of patients are in the pipeline.

Bidragets oversatte titelMyelodysplastic syndrome and acut leukaemia
OriginalsprogDansk
ArtikelnummerV03210202
TidsskriftUgeskrift for laeger
Vol/bind183
Udgave nummer20A
Sider (fra-til)1952-1957
Antal sider6
ISSN0041-5782
StatusUdgivet - 18 okt. 2021

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