TY - JOUR
T1 - National Surveillance of fungemia in Denmark (2004 to 2009)
AU - Arendrup, Maiken Cavling
AU - Bruun, Brita
AU - Christensen, Jens Jørgen
AU - Fuursted, Kurt
AU - Johansen, Helle Krogh
AU - Kjældgaard, Poul
AU - Knudsen, Jenny Dahl
AU - Kristensen, Lise
AU - Møller, Jens
AU - Nielsen, Lene
AU - Rosenvinge, Flemming Schønning
AU - Røder, Bent
AU - Schønheyder, Henrik Carl
AU - Thomsen, Marianne K
AU - Truberg, Kjeld
PY - 2011
Y1 - 2011
N2 - A 6-year nationwide study of fungemia in Denmark was performed using data from an active fungemia surveillance programme and from laboratory information systems in non-participating regions. A total of 2,820 episodes of fungemia were recorded. The incidence increased 2004-2007 (7.7-9.6/100,000) and decreased slightly 2008-2009 (8.7-8.6/100,000). The highest incidences were seen at the extremes of age (i.e. 11.3 and 37.1/100,000 in the <1 and 70-79 years, respectively. The rate was higher in males than in females (10.1 vs. 7.6/100,000, P=0.003) with the largest difference observed for patients 50+ years of age. The species distribution varied significantly by both age and gender. Candida species accounted for 98% of the pathogens and C. albicans was predominant although the proportion decreased (64.4% to 53.2%, P<0.0001). C. glabrata ranked second and the proportion increased (16.5% to 25.9%, P=0.003). C. glabrata was more common in adults and females compared to children and males, whereas C. tropicalis was more common in males (P=0.020). C. krusei was a rare isolate (4.1%) except at one university hospitals. Acquired resistance to amphotericin and echinocandins was rare. However, resistance to fluconazole (MIC>4 μg/ml) occurred in: C. albicans 7/1183 (0.6%), C. dubliniensis 2/65 (3.1%), C. parapsilosis 5/83 (6.0%) and C. tropicalis 7/104 (6.7%). Overall, 70.8% of fungemia isolates were fully fluconazole susceptible but the proportion decreased (79.7% to 68.9%, P=0.02). The study confirmed a three times higher incidence rate of fungemia in Denmark compared to other Nordic countries and identified marked differences related to age and gender. Decreased susceptibility to fluconazole was frequent and increasing.
AB - A 6-year nationwide study of fungemia in Denmark was performed using data from an active fungemia surveillance programme and from laboratory information systems in non-participating regions. A total of 2,820 episodes of fungemia were recorded. The incidence increased 2004-2007 (7.7-9.6/100,000) and decreased slightly 2008-2009 (8.7-8.6/100,000). The highest incidences were seen at the extremes of age (i.e. 11.3 and 37.1/100,000 in the <1 and 70-79 years, respectively. The rate was higher in males than in females (10.1 vs. 7.6/100,000, P=0.003) with the largest difference observed for patients 50+ years of age. The species distribution varied significantly by both age and gender. Candida species accounted for 98% of the pathogens and C. albicans was predominant although the proportion decreased (64.4% to 53.2%, P<0.0001). C. glabrata ranked second and the proportion increased (16.5% to 25.9%, P=0.003). C. glabrata was more common in adults and females compared to children and males, whereas C. tropicalis was more common in males (P=0.020). C. krusei was a rare isolate (4.1%) except at one university hospitals. Acquired resistance to amphotericin and echinocandins was rare. However, resistance to fluconazole (MIC>4 μg/ml) occurred in: C. albicans 7/1183 (0.6%), C. dubliniensis 2/65 (3.1%), C. parapsilosis 5/83 (6.0%) and C. tropicalis 7/104 (6.7%). Overall, 70.8% of fungemia isolates were fully fluconazole susceptible but the proportion decreased (79.7% to 68.9%, P=0.02). The study confirmed a three times higher incidence rate of fungemia in Denmark compared to other Nordic countries and identified marked differences related to age and gender. Decreased susceptibility to fluconazole was frequent and increasing.
U2 - 10.1128/JCM.01811-10
DO - 10.1128/JCM.01811-10
M3 - Journal article
SN - 0095-1137
VL - 49
SP - 325
EP - 334
JO - Journal of Clinical Microbiology
JF - Journal of Clinical Microbiology
ER -